ArticleThe Journal of nutritional biochemistry2018
Copper supplementation reverses dietary iron overload-induced pathologies in mice.
Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Changes in the distribution of elements in the liver and various brain regions in suicides from southeastern Poland.Scientific reports · 2025Article
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- Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies.Cell death discovery · 2024Review
- Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies.Frontiers in pharmacology · 2024Review
- Association of four metalloids in the serum and urine of individuals with major depressive disorders: a case-control study.Frontiers in psychiatry · 2024Article
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- The emerging role of copper in depression.Frontiers in neuroscience · 2023Review
- Comparison of apical and basolateral Cu treatment for iron-related gene regulation during deferoxamine induced iron deficiency.Genes & nutrition · 2022Article
- A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice.Scientific reports · 2022Article
- Dietary Iron Intake in Excess of Requirements Impairs Intestinal Copper Absorption in Sprague Dawley Rat Dams, Causing Copper Deficiency in Suckling Pups.Biomedicines · 2021Article
- The selfishly selfless placenta.The Journal of clinical investigation · 2020Article
- Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation.Frontiers in bioengineering and biotechnology · 2020Review
- Animal Models of Normal and Disturbed Iron and Copper Metabolism.The Journal of nutrition · 2019Review
- Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations.Hepatology communications · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Dietary iron overload in rodents impairs growth and causes cardiac hypertrophy, serum and tissue copper depletion, depression of serum ceruloplasmin (Cp) activity and anemia. Notably, increasing dietary copper content to ~25-fold above requirements prevents the development of these physiological perturbations. Whether copper supplementation can reverse these high-iron-related abnormalities has, however, not been established. The current investigation was thus undertaken to test the hypothesis that supplemental copper will mitigate negative outcomes associated with dietary iron loading. Weanling mice were thus fed AIN-93G-based diets with high (>100-fold in excess) or adequate (~80 ppm) iron content. To establish the optimal experimental conditions, we first defined the time course of iron loading, and assessed the impact of supplemental copper (provided in drinking water) on the development of high-iron-related pathologies. Copper supplementation (20 mg/L) for the last 3 weeks of a 7-week high-iron feeding period reversed the anemia, normalized serum copper levels and Cp activity, and restored tissue copper concentrations. Growth rates, cardiac copper concentrations and heart size, however, were only partially normalized by copper supplementation. Furthermore, high dietary iron intake reduced intestinal
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Registered trials
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