ArticleNeuroscience bulletin2018
Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness.
Article in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Microstate permutation complexity of EEG signals distinguishes minimally conscious state plus from minimally conscious state minus.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Brain Metabolic Connectivity Patterns in Patients with Prolonged Disorder of Consciousness after Hypoxic-Ischemic Injury: A Preliminary Study.Brain sciences · 2022Article
- Corticothalamic Connectivity in Aneurysmal Subarachnoid Hemorrhage: Relationship with Disordered Consciousness and Clinical Outcomes.Neurocritical care · 2022Article
- A prediction model of clinical outcomes in prolonged disorders of consciousness: A prospective cohort study.Frontiers in neuroscience · 2022Article
- Disruptions in Effective Connectivity within and between Default Mode Network and Anterior Forebrain Mesocircuit in Prolonged Disorders of Consciousness.Brain sciences · 2021Article
- Time-delay structure predicts clinical scores for patients with disorders of consciousness using resting-state fMRI.NeuroImage. Clinical · 2021Article
- Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness.Frontiers in neuroscience · 2021Article
- Pharmacologically informed machine learning approach for identifying pathological states of unconsciousness via resting-state fMRI.NeuroImage · 2020Article
- Abnormal dynamic properties of functional connectivity in disorders of consciousness.NeuroImage. Clinical · 2019Article
- Recent Progress in Basic and Clinical Research on Disorders of Consciousness.Neuroscience bulletin · 2018Article
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Authors and funding
13 authors.
Funding
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Abstract
A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
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