Evidence map›Paper›PMID 29959659›Full record

ArticleInternational ophthalmology2019

Fumaric acid: a possible new therapy for macular edema?

Lukas Kofler, Sabine Kathrein-Schneider, Katrin Schweinzer, Heinz Kofler

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In one paragraph

Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Lukas KoflerDermatologische Praxis und Allergieambulatorium Hall i.T, Thurnfeldgasse 3a, 6060, Hall in Tirol, Austria. lukas.kofler@kofler-haut.at.ORCID http://orcid.org/0000-0003-2404-5388
Sabine Kathrein-SchneiderOpthalmologische Praxis Hall i.T, Staubstraße 1, 6060, Hall in Tirol, Austria.
Katrin SchweinzerDepartment of Dermatology, Eberhard-Karls University Tübingen, Liebermeisterstraße 25, 72076, Tübingen, Germany.
Heinz KoflerDermatologische Praxis und Allergieambulatorium Hall i.T, Thurnfeldgasse 3a, 6060, Hall in Tirol, Austria.
Tirol Kliniken · ATKohler (New Zealand) · NZUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCauses of macular edema are multifactorial, but inflammation, vascular factors and mechanical traction are of major importance. Therapeutic options of macular edema depend on the underlying cause. Intravitreal administration of inhibitors of vascular endothelial growth factor leads to inhibition of retinal neovascularization and subsequent edema.

objectiveFumaric acid esters are successfully used in dermatology for years according to their antiangiogenic and anti-inflammatory effects.

resultFor the very first time, we describe a successful therapeutic attempt for macular edema, controlled by optical coherence tomography using fumaric acid esters followed up for 60 months.

Indexed as

Administration, OralAged, 80 and overDimethyl FumarateFemaleFluorescein AngiographyFundus OculiHumansImmunosuppressive AgentsMacula LuteaMacular EdemaTomography, Optical CoherenceDimethyl FumarateImmunosuppressive AgentsFumaric acid esterHIF-1aMacular edemaNeoangiogenesisTranscription factor NK-kBVEGF

Identifiers

PMID29959659
OpenAlexW2810558119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.