Evidence map›Paper›PMID 29959498›Full record

SynthesisDer Anaesthesist2018

[Rapid sequence induction and intubation in patients with risk of aspiration : Recommendations for action for practical management of anesthesia].

C Eichelsbacher, H Ilper, R Noppens, J Hinkelbein, T Loop

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Der Anaesthesist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Preoperative fasting guidelines: A narrative review.European journal of anaesthesiology and intensive care · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Use of Muscle Relaxants in Emergency Medicine: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Review
  9. SAFE anaesthesia for patients at risk of pulmonary aspiration: A nationwide survey.European journal of anaesthesiology and intensive care · 2025
    Article
  10. Article
  11. Sugammadex in Emergency Situations.Journal of personalized medicine · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. ORi™: a new indicator of oxygenation.Journal of anesthesia · 2021
    Review
  16. Article
  17. Article
  18. Rapid sequence induction: An international survey.European journal of anaesthesiology · 2020
    Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

C EichelsbacherKlinik für Anästhesiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland.
H IlperKlinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Frankfurt, Frankfurt a.M., Deutschland.
R NoppensAnesthesia & Perioperative Medicine, University Hospital, London, Ontario, Kanada.
J HinkelbeinKlinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln (AöR), Köln, Deutschland.
T LoopKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Freiburg, Hugstetter Straße 55, 79106, Freiburg im Breisgau, Deutschland. torsten.loop@uniklinik-freiburg.de.
Goethe University Frankfurt · DEJohannes Gutenberg University Mainz · DEUniversity Hospital Cologne · DEUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInduction of general anesthesia in patients with risk for aspiration needs special considerations to avoid the incidence and severity of complications. Since no evidence-based guidelines support the challenge for anesthesiologists various practical recommendations exist in clinical practice for rapid sequence induction and intubation (RSI). The aim of this systematic review is, to summarize the evidence and recommend a decision making process. MATERIAL AND

methodsMultilevel RAND-delphi-method (RAND: Research and Development) combined with systematic literature research, individual assessment and evaluation, consensus conferences and final common sequence. RESULTS AND DISCUSSION: The consideration of all practical, clinical procedures in patients at risk for aspiration represents an effective prevention of pulmonary aspiration during the induction of anesthesia. These include the optimal drug pre-treatment with antacids (e. g. sodium citrate) for highly aspiration-endangered and proton pump inhibitors or H2 blockers in other patients the evening before. Each patient should be examined and explained prior to RSI according to the recommendations of the National German Society of Anesthesiology for preoperative evaluation. A RSI should be performed in patients with no 2h liquid and no 6h food fasting or acute vomiting, sub-ileus or ileus, or no protective reflexes or a gastrointestinal passenger disorder. In addition, RSI should be performed in pregnant women after the 3rd trimester and during birth. The expertise and competence of the physician before and during rapid sequence induction and intubation about the respective task distribution minimizes the risk of aspiration, as does the adequate equipment, as well as an optimized upper body elevation of the patient. Consistent pre-oxygenation with an F

Indexed as

Anesthesia, GeneralAnesthesiologyCapnographyHumansHypnotics and SedativesIntubation, IntratrachealNeuromuscular Depolarizing AgentsPneumonia, AspirationRiskHypnotics and SedativesNeuromuscular Depolarizing AgentsGeneral anesthesiaRapid sequence inductionRespiratory aspiration

Identifiers

PMID29959498
OpenAlexW2811189774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.