Observational studyIntensive care medicine2018
Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study.
Observational study in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Risk prediction models for diabetic nephropathy among type 2 diabetes patients in China: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Early Prediction of Sepsis in the ICU Using Machine Learning: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy.Intensive care medicine · 2020Pooled it
- Development and validation of an early diagnostic model to distinguish bacterial infection in patients with acute-on-chronic liver disease (AoCLD) and systemic inflammatory response syndrome (SIRS): a post-hoc analysis of a prospective multicenter cohort.Journal of advanced research · 2026Article
- Severe community-acquired pneumonia: current concepts and controversies.Intensive care medicine · 2026Review
- Observational
- Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis.Frontiers in immunology · 2026Observational
- Marked Non-Infectious Elevation of Procalcitonin in a Hemodialysis Patient with Bladder Cancer: A Case Report.Infection and drug resistance · 2026Article
- Clinical and microbiological characteristics of bacteremia in pediatric intensive care unit: a retrospective analytical observational study.BMC pediatrics · 2025Observational
- Transcriptional characterization of sepsis in a LPS porcine model.Molecular genetics and genomics : MGG · 2025Article
- Identification and Validation of an Explainable Prediction Model of Sepsis in Patients With Intracerebral Hemorrhage: Multicenter Retrospective Study.Journal of medical Internet research · 2025Article
- Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis.Molecular medicine (Cambridge, Mass.) · 2025Review
- Exploring the Potentials of Artificial Intelligence in Sepsis Management in the Intensive Care Unit.Critical care research and practice · 2025Review
- Efficient sepsis detection using deep learning and residual convolutional networks.PeerJ. Computer science · 2025Article
- Decoy receptor 3 as a prognostic biomarker for sepsis and septic shock according to the Sepsis-3 definitions.Frontiers in cellular and infection microbiology · 2025Article
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
- Comparison of the accuracy of procalcitonin, neutrophil CD64, and C-reactive protein for the diagnosis and prognosis of septic patients after antibiotic therapy.Practical laboratory medicine · 2025Article
- Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial.Annals of intensive care · 2024Article
- Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Measurement of Pancreatic Stone Protein Compared with C-Reactive Protein and Procalcitonin in the Diagnosis of Sepsis in an Intensive Care Unit: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
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Authors and funding
20 authors at 6 institutions in 1 country.
Funding
Abstract
purposeSepsis and non-septic systemic inflammatory response syndrome (SIRS) are the same syndromes, differing by their cause, sepsis being secondary to microbial infection. Microbiological tests are not enough to detect infection early. While more than 50 biomarkers have been proposed to detect infection, none have been repeatedly validated.
aimTo assess the accuracy of circulating biomarkers to discriminate between sepsis and non-septic SIRS.
methodsThe CAPTAIN study was a prospective observational multicenter cohort of 279 ICU patients with hypo- or hyperthermia and criteria of SIRS, included at the time the attending physician considered antimicrobial therapy. Investigators collected blood at inclusion to measure 29 plasma compounds and ten whole blood RNAs, and-for those patients included within working hours-14 leukocyte surface markers. Patients were classified as having sepsis or non-septic SIRS blindly to the biomarkers results. We used the LASSO method as the technique of multivariate analysis, because of the large number of biomarkers.
resultsDuring the study period, 363 patients with SIRS were screened, 84 having exclusion criteria. Ninety-one patients were classified as having non-septic SIRS and 188 as having sepsis. Eight biomarkers had an area under the receiver operating curve (ROC-AUC) over 0.6 with a 95% confidence interval over 0.5. LASSO regression identified CRP and HLA-DRA mRNA as being repeatedly associated with sepsis, and no model performed better than CRP alone (ROC-AUC 0.76 [0.68-0.84]).
conclusionsThe circulating biomarkers tested were found to discriminate poorly between sepsis and non-septic SIRS, and no combination performed better than CRP alone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.