Evidence map›Paper›PMID 29959412›Full record

ArticleScientific reports2018

Light Emitting Diodes based Photoacoustic Imaging and Potential Clinical Applications.

Yunhao Zhu, Guan Xu, Jie Yuan, Janggun Jo, Girish Gandikota, Hakan Demirci, Toshitaka Agano, Naoto Sato, Yusuke Shigeta, Xueding Wang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yunhao ZhuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Guan XuDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Jie YuanDepartment of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, 21000, China. yuanjie@nju.edu.cn.
Janggun JoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Girish GandikotaDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Hakan DemirciKellogg Eye Center, University of Michigan, Ann Arbor, Michigan, 48109, USA.
Toshitaka AganoPreXion Corporation, Tokyo, 1010041, Japan.
Naoto SatoPreXion Corporation, Tokyo, 1010041, Japan.
Yusuke ShigetaPreXion Corporation, Tokyo, 1010041, Japan.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA. xdwang@umich.edu.
University of Michigan–Ann Arbor · USNanjing University · CNW.K. Kellogg Foundation · US

Funding

Physiology of Inflammatory Arthritis in High ResolutionR01AR060350 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, XUEDING · 2011 to 2021
$6.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 1R21AI12209801A1National Natural Science Foundation of China (National Science Foundation of China) 11574231,61201425NIAMS NIH HHS R01 AR060350
6 · The paper itself

Abstract

Using low cost and small size light emitting diodes (LED) as the alternative illumination source for photoacoustic (PA) imaging has many advantages, and can largely benefit the clinical translation of the emerging PA imaging technology. Here, we present our development of LED-based PA imaging integrated with B-mode ultrasound. To overcome the challenge of achieving sufficient signal-to-noise ratio by the LED light that is orders of magnitude weaker than lasers, extensive signal averaging over hundreds of pulses is performed. Facilitated by the fast response of the LED and the high-speed driving as well as the high pulse repetition rate up to 16 kHz, B-mode PA images superimposed on gray-scale ultrasound of a biological sample can be achieved in real-time with frame rate up to 500 Hz. The LED-based PA imaging could be a promising tool for several clinical applications, such as assessment of peripheral microvascular function and dynamic changes, diagnosis of inflammatory arthritis, and detection of head and neck cancer.

Indexed as

LightSemiconductorsArthritisCosts and Cost AnalysisEquipment DesignEye NeoplasmsHumansPhotoacoustic TechniquesSafety

Identifiers

PMID29959412
PMCPMC6026116
OpenAlexW2811026482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.