ArticleScientific reports2018
Genetic Factors and Genotype-Environment Interactions Contribute to Variation in Melanin Production in the Fungal Pathogen Cryptococcus neoformans.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Conserved and rewired MAPK networks in human fungal pathogens.FEMS yeast research · 2026Review
- Investigation of the influence of pH and temperature on melanization and survival under oxidative stress in Cryptococcus neoformans.Archives of microbiology · 2024Article
- A Cyclam Salt as an Antifungal Agent: Interference withAntibiotics (Basel, Switzerland) · 2024Article
- Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics againstFrontiers in microbiology · 2023Article
- FasterJournal of fungi (Basel, Switzerland) · 2022Article
- Phenotypic Plasticity in the Productions of Virulence Factors Within and Among Serotypes in the Cryptococcus neoformans Species Complex.Mycopathologia · 2022Article
- Horse: a potential source of Cryptococcus neoformans and Cryptococcus gattii in Egypt.BMC veterinary research · 2022Article
- The first survey of cryptococcal cells in bird droppings across Bloemfontein, South Africa.Veterinary world · 2021Article
- The Environmental Effects on Virulence Factors and the Antifungal Susceptibility ofInternational journal of molecular sciences · 2021Review
- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.PLoS genetics · 2021Article
- Population diversity and virulence characteristics of Cryptococcus neoformans/C. gattii species complexes isolated during the pre-HIV-pandemic era.PLoS neglected tropical diseases · 2020Article
- Multi-locus Sequence Typing and Whole Genome Sequence Analysis of Cryptococcus neoformans Isolated from Clinical Specimens in Vajira Hospital, Bangkok, Thailand.Mycopathologia · 2020Article
- Genotypes and population genetics of cryptococcus neoformans and cryptococcus gattii species complexes in Europe and the mediterranean area.Fungal genetics and biology : FG & B · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 6 institutions in 6 countries.
Funding
Abstract
Cryptococcosis is a common opportunistic fungal infection that often disseminates into the central nervous system, leading to meningitis. Production of melanin pigments during infections is one of the most important virulence factors of its causal agent, the human pathogenic yeast Cryptococcus neoformans species complex. However, almost nothing is known about the patterns of variation in melanin production among clinical and environmental strains and the potential effects of such variations on virulence. In this study, we assembled a global collection of C. neoformans var. neoformans strains and investigated their patterns of melanin variation and potential contributors to such variations. Our analyses revealed that genetic differences and genotype-environment interactions explained up to 59% and 43% of the population's melanin variance respectively, depending on the tested environments. In comparison, environmental factors alone contributed relatively little to melanin variance. We also identified specific changes within the LAC1 gene, whose protein product catalyzes melanin synthesis, to be associated with variable melanin levels. This study provides fresh insights into the origin and evolution of virulence traits in fungal pathogens while highlighting the complex interplay between genetic and environmental factors that lead to phenotypic variance.
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