Evidence map›Paper›PMID 29959380›Full record

ArticleScientific reports2018

Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.

Amy K Cain, Christine J Boinett, Lars Barquist, Janina Dordel, Maria Fookes, Matthew Mayho, Matthew J Ellington, David Goulding, Derek Pickard, Ryan R Wick and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Systematic review of multidrug-resistantFrontiers in microbiology · 2025
    Pooled it
  2. Article
  3. Article
  4. Virulence · 2025
    Article
  5. Article
  6. Article
  7. O-antigen polysaccharides inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Genome-Wide Analysis of Innate Susceptibility Mechanisms ofAntibiotics (Basel, Switzerland) · 2022
    Article
  12. Review
  13. Article
  14. Antibiotic Heteroresistance inInternational journal of molecular sciences · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Population genomics of Klebsiella pneumoniae.Nature reviews. Microbiology · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Amy K Cain *Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. ac19@sanger.ac.uk.
Christine J Boinett *Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. cb19@sanger.ac.uk.
Lars BarquistHelmholtz Institute for RNA-based Infection Research, Würzburg, D-97080, Germany.
Janina DordelDepartment of Biology, Drexel University, Philadelphia, 19104, PA, USA.
Maria FookesWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Matthew MayhoWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Matthew J EllingtonPublic Health England, 61 Colindale Avenue, London, NW9 5EQ, UK.
David GouldingWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Derek PickardWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Ryan R WickCentre for Systems Genomics, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-8349-0778
Kathryn E HoltCentre for Systems Genomics, The University of Melbourne, Melbourne, VIC, Australia.
Julian ParkhillWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0002-7069-5958
Nicholas R ThomsonWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. nrt@sanger.ac.uk.
Wellcome Sanger Institute · GBThe University of Melbourne · AUDrexel University · USHelmholtz Institute for RNA-based Infection Research · DEPublic Health England · GB

Funding

Medical Research Council G1100100Wellcome TrustWellcome Trust WT098051
6 · The paper itself

Abstract

Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of col

Indexed as

GenomicsAnti-Bacterial AgentsColistinDrug Resistance, BacterialGenes, BacterialGenotypeKlebsiella pneumoniaeMutationPhenotypePhylogenyTranscriptomeAnti-Bacterial AgentsColistin

Identifiers

PMID29959380
PMCPMC6026146
OpenAlexW2809749880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.