Evidence map›Paper›PMID 29959357›Full record

ArticleScientific reports2018

Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation.

Xiaoli Wang, Heng Wang, Joseph F Pierre, Sheng Wang, Huifang Huang, Jun Zhang, Shuangzhen Liang, Qingzhu Zeng, Chenqing Zhang, Meijuan Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoli WangInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Heng WangInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Joseph F PierreSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.
Sheng WangDepartment of Human Genetics, The University of Chicago, Chicago, IL, 60637, USA.
Huifang HuangCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Jun ZhangInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Shuangzhen LiangInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Qingzhu ZengInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Chenqing ZhangInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Meijuan HuangCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Chengxu RuanInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China.
Juan LinFujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fuzhou, Fujian, China.
Hao LiInstitute of Applied Biotechnology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, 350116, China. haoli@fzu.edu.cn.

Funding

Department of Education, Fujian Province (Fujian Educational Department) 2015002Fujian Provincial Department of Science and Technology (Department of Science and Technology of Fujian Province) 2014Y005
6 · The paper itself

Abstract

Bioengineered marine microalgae Schizochytrium sp. is currently used to produce docosahexaenoic acid (DHA). However, following DHA extraction, the remaining protein-rich materials are not well utilized. In this study, we report that marine microalgae bioengineered Schizochytrium sp. hydrolysate (MESH), which exhibits a unique peptide profile as identified by Ultra Performance Liquid Chromatography coupled with Q-TOF mass spectrometry(UPLC/Q-TOF-MS), ameliorated bowel inflammation in mice. In a mouse model of experimentalcolitis induced by dextran sulfate sodium, compared with the control mice, the mice treated with MESH were highly resistant to colitis, as demonstrated by marked reductions in body weight loss, clinical colitis scores, colonic histological damage, and colonic inflammation. Mechanistically, MESH attenuated the induction of pro-inflammatory cytokines and increased the induction of anti-inflammatory cytokines. MESH also promoted the proliferation of colonic crypt stem cells and progenitor cells required for crypt repair. Collectively, these results reveal a previously unrecognized role of MESH as a potential anti-inflammatory treatment for colitis.

Indexed as

MealsAcute DiseaseAnimalsCells, CulturedColitisDextran SulfateDocosahexaenoic AcidsInflammationIntestinal MucosaMaleMiceMice, Inbred C57BLMicroalgaePeptide FragmentsRatsDextran SulfateDocosahexaenoic AcidsPeptide Fragments

Identifiers

PMID29959357
PMCPMC6026148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.