ArticleScientific reports2018
Human and Microbial Proteins From Corpora Amylacea of Alzheimer's Disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.GeroScience · 2019Trial
- Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space.Brain pathology (Zurich, Switzerland) · 2026Article
- Wasteosomes (corpora amylacea) of the human brain accumulate in CD44-positive astrocytes.iScience · 2026Article
- Proteomic Analysis of Corpora Amylacea Extracted From Post-mortem Brain of MAiD-end-of-life Sporadic ALS Patients.Brain and behavior · 2026Article
- The microbiota-gut-brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets.The FEBS journal · 2025Review
- Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology.Acta neuropathologica communications · 2024Article
- Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Wasteosomes (Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages.Cell & bioscience · 2022Article
- Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia.Cell and tissue research · 2022Article
- Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.Acta neuropathologica communications · 2022Article
- Is Alzheimer's disease an infectious neurological disease? A review of the literature.Brain and behavior · 2022Review
- Alzheimer's disease is an inherent, natural part of human brain aging: an integrated perspective.Free neuropathology · 2022Article
- Quantitative analysis of size and regional distribution of corpora amylacea in the hippocampal formation of obstructive sleep apnoea patients.Scientific reports · 2021Article
- Multi-pathogen infections and Alzheimer's disease.Microbial cell factories · 2021Review
- Corpora Amylacea in the Human Brain Exhibit Neoepitopes of a Carbohydrate Nature.Frontiers in immunology · 2021Article
- Lipopolysaccharide, Identified Using an Antibody and by PAS Staining, Is Associated WithFrontiers in aging neuroscience · 2021Article
- Article
- Parkinson's Disease: A Comprehensive Analysis of Fungi and Bacteria in Brain Tissue.International journal of biological sciences · 2020Article
- Brain Microbiota in Huntington's Disease Patients.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corpora amylacea (CA) are spherical bodies mainly composed of polyglucans and, to a lesser extent, proteins. They are abundant in brains from patients with neurodegenerative diseases, particularly Alzheimer's disease. Although CA were discovered many years ago, their precise origin and function remain obscure. CA from the insular cortex of two Alzheimer's patients were purified and the protein composition was assessed by proteomic analysis. A number of microbial proteins were identified and fungal DNA was detected by nested PCR.A wide variety of human proteins form part of CA. In addition, we unequivocally demonstrated several fungal and bacterial proteins in purified CA. In addition to a variety of human proteins, CA also contain fungal and bacterial polypeptides.In conclusion, this paper suggests that the function of CA is to scavenge cellular debris provoked by microbial infections.
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