Evidence map›Paper›PMID 29959282›Full record

ArticleRNA (New York, N.Y.)2018

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys.

Marilyn Parra, Ben W Booth, Richard Weiszmann, Brian Yee, Gene W Yeo, James B Brown, Susan E Celniker, John G Conboy

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marilyn ParraBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Ben W BoothBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Richard WeiszmannBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Brian YeeDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92037, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92037, USA.
James B BrownEnvironmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Susan E CelnikerBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
John G ConboyBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Lawrence Berkeley National Laboratory · USNational University of Singapore · SGUniversity of California San Diego · US

Funding

Comprhensive analysis of functional RNA elements encoded in the human genomeU54HG007005 · NHGRI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2012 to 2017
$12.5M
Functional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4M
Intron Retention Mechanisms that Regulate Erythroid SF3B1 Gene ExpressionR01DK108020 · NIDDK · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CONBOY, JOHN G · 2016 to 2018
$1.1M
Nonparametric methods for functional and translational genomicsR00HG006698 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BROWN, JAMES BENTLEY · 2014 to 2016
$747k
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
NHGRI NIH HHS R00 HG006698NHGRI NIH HHS R01 HG004659NHGRI NIH HHS U54 HG007005NIDDK NIH HHS R01 DK108020NIH HHS S10 OD018174
6 · The paper itself

Abstract

During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes. We studied IR mechanisms in the

Indexed as

Alternative SplicingCell DifferentiationCells, CulturedErythroblastsExonsHumansIntronsNonsense Mediated mRNA DecayProtein IsoformsRNA Splice SitesRNA Splicing FactorsSequence Analysis, RNASplicing Factor U2AFProtein IsoformsRNA Splice SitesRNA Splicing FactorsSF3B4 protein, humanSplicing Factor U2AFU2AF1 protein, humanU2AF2 protein, humanalternative splicingintron retentionSF3B1

Identifiers

PMID29959282
PMCPMC6097662
OpenAlexW2950670315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.