Evidence map›Paper›PMID 29959237›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Muscarinic Receptor M

R Ross Welliver, Jessie J Polanco, Richard A Seidman, Anjali K Sinha, Melanie A O'Bara, Zainab M Khaku, Diara A Santiago González, Akiko Nishiyama, Jurgen Wess, M Laura Feltri and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  10. Article
  11. A preliminary study of the effects of an antimuscarinic agent on anxious behaviors and white matter microarchitecture in nonhuman primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  12. Article
  13. Lysophosphatidic acid signaling via LPAJournal of neurochemistry · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  18. Review
  19. MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord.Journal of the American Society for Mass Spectrometry · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

R Ross WelliverNeuroscience Program.
Jessie J PolancoNeuroscience Program.
Richard A SeidmanNeuroscience Program.
Anjali K SinhaNeuroscience Program.
Melanie A O'BaraDepartment of Pharmacology and Toxicology, and.
Zainab M KhakuDepartment of Pharmacology and Toxicology, and.
Diara A Santiago GonzálezDepartment of Pharmacology and Toxicology, and.ORCID 0000-0001-8413-4046
Akiko NishiyamaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, and.ORCID 0000-0001-7252-0812
Jurgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
M Laura FeltriNeuroscience Program.ORCID 0000-0002-2276-9182
Pablo M PaezNeuroscience Program.ORCID 0000-0001-9362-9454
Fraser J SimNeuroscience Program, fjsim@buffalo.edu.ORCID 0000-0002-3942-6637
Society for Neuroscience · USNational Institutes of Health · USUniversity at Buffalo, State University of New York · USUniversity of Connecticut · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Muscarinic acetylcholine receptor subtypes: physiological rolesZIADK075020 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI WESS, JURGEN · 2009 to 2025
$6.1M
Enabling Access to Cutting-Edge Biomedical and Behavioral ScienceR25GM095459 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2012 to 2021
$4.4M
Muscarinic Receptor Type 3 Regulation of Oligodendrocyte Progenitor DifferentiationR01NS104021 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2018 to 2022
$1.7M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NIGMS NIH HHS R25 GM095459NINDS NIH HHS R01 NS104021
6 · The paper itself

Abstract

Muscarinic receptor antagonists act as potent inducers of oligodendrocyte differentiation and accelerate remyelination. However, the use of muscarinic antagonists in the clinic is limited by poor understanding of the operant receptor subtype, and questions regarding possible species differences between rodents and humans. Based on high selective expression in human oligodendrocyte progenitor cells (OPCs), we hypothesized that M

Indexed as

AnimalsBrain Tissue TransplantationCalcium SignalingCells, CulturedFetal Tissue TransplantationGene Knockdown TechniquesHumansMiceMice, Neurologic MutantsMuscarinic AgonistsMuscarinic AntagonistsMyelin SheathNeurogenesisOligodendrocyte Precursor CellsProsencephalonReceptor, Muscarinic M3CHRM3 protein, humanChrm3 protein, mouseMuscarinic AgonistsMuscarinic AntagonistsReceptor, Muscarinic M3CHRM3demyelinationhumanlentivirusremyelinationtransplantation

Identifiers

PMID29959237
PMCPMC6070663
OpenAlexW2811356603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.