Evidence map›Paper›PMID 29959226›Full record

ArticleThe Journal of biological chemistry2018

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process.

Saima Limi, Adrien Senecal, Robert Coleman, Melissa Lopez-Jones, Peng Guo, Christina Polumbo, Robert H Singer, Arthur I Skoultchi, Ales Cvekl

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  6. A novel frameshift variant inOphthalmic genetics · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. RNA velocity unraveled.PLoS computational biology · 2022
    Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Saima LimiFrom the Departments of Genetics.
Adrien SenecalAnatomy and Structural Biology.
Robert ColemanAnatomy and Structural Biology.
Melissa Lopez-JonesAnatomy and Structural Biology.
Peng GuoAnatomy and Structural Biology.
Christina PolumboAnatomy and Structural Biology.
Robert H SingerAnatomy and Structural Biology.
Arthur I SkoultchiCell Biology.
Ales CveklFrom the Departments of Genetics, ales.cvekl@einstein.yu.edu.ORCID 0000-0002-3957-789X
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
PAX-6 AS A KEY REGULATOR OF LENS DEVELOPMENTR01EY012200 · NEI · YESHIVA UNIVERSITY · PI CVEKL, ALES · 2000 to 2025
$13.1M
Transcriptional Control of the Mouse aA-crystallin locusR01EY014237 · NEI · YESHIVA UNIVERSITY · PI Ales Cvekl · 2003 to 2026
$11.0M
Tools For Imaging the Functional Genome in Living Cells and TissuesU01EB021236 · NIBIB · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DARZACQ, XAVIER, SINGER, ROBERT H · 2015 to 2017
$2.5M
Control of the Erythroid Terminal Differentiation DecisionR01DK096266 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SKOULTCHI, ARTHUR I · 2012 to 2016
$1.8M
Tools For Imaging the Functional Genome in Living Cells and TissuesU01DA047729 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DARZACQ, XAVIER, SINGER, ROBERT H · 2018 to 2019
$1.7M
NCI NIH HHS P30 CA013330NEI NIH HHS R01 EY012200NEI NIH HHS R01 EY014237NIBIB NIH HHS U01 EB021236NIDA NIH HHS U01 DA047729NIDDK NIH HHS R01 DK096266NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

Genes are transcribed in irregular pulses of activity termed transcriptional bursts. Cellular differentiation requires coordinated gene expression; however, it is unknown whether the burst fraction (

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalOrganogenesisTranscription, GeneticAnimalsAnimals, NewbornCell NucleusChromatin Assembly and DisassemblyEmbryo, MammalianFemaleLens, CrystallineMicechromatin remodelingcrystallinDenucleationdifferentiationgene transcriptionlensnascent transcriptionRNA FISHSnf2h (Smarca5)transcriptional bursting

Identifiers

PMID29959226
PMCPMC6109918
OpenAlexW2810696621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.