Evidence map›Paper›PMID 29959215›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Evaluation of Two Potent and Selective PET Radioligands to Image COX-1 and COX-2 in Rhesus Monkeys.

Min-Jeong Kim, Stal S Shrestha, Michelle Cortes, Prachi Singh, Cheryl Morse, Jeih-San Liow, Robert L Gladding, Chad Brouwer, Katharine Henry, Evan Gallagher and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  3. Trial
  4. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  5. Article
  6. A comprehensive review ofMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  7. Article
  8. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Whole-Body PET Imaging in Humans Shows ThatJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Review
  14. Repurposing [Molecular imaging and biology · 2022
    Article
  15. Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  16. Review
  17. Towards PET imaging of the dynamic phenotypes of microglia.Clinical and experimental immunology · 2021
    Review
  18. NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  19. Is cyclooxygenase-1 involved in neuroinflammation?Journal of neuroscience research · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Min-Jeong KimMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland min-jeong.kim@nih.gov.
Stal S ShresthaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Michelle CortesMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Prachi SinghMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Cheryl MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Robert L GladdingMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Chad BrouwerMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Katharine HenryMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Evan GallagherMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
George L TyeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Masahiro FujitaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USNational Institute of Mental Health · US

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
NIMH NIH HHS ZIA MH002793NIMH NIH HHS ZIA MH002795
6 · The paper itself

Abstract

This study assessed whether the newly developed PET radioligands

Indexed as

RadiopharmaceuticalsAnimalsCarbon RadioisotopesCyclooxygenase 1Cyclooxygenase 2FemaleMacaca mulattaMalePositron-Emission TomographyPyrimidinesRadioligand AssayTissue DistributionTriazolesWhole Body Imaging(11C)-MC111C-PS13Carbon-11Carbon RadioisotopesCyclooxygenase 1Cyclooxygenase 2PyrimidinesRadiopharmaceuticalsTriazolescyclooxygenase-1cyclooxygenase-2inflammationnonsteroidal antiinflammatory agentspositron-emission tomography

Identifiers

PMID29959215
PMCPMC6278897
OpenAlexW2810109776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.