Evidence map›Paper›PMID 29959195›Full record

ReviewCold Spring Harbor perspectives in biology2019

Principles of Translational Control.

John W B Hershey, Nahum Sonenberg, Michael B Mathews

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed.

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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John W B HersheyDepartment of Biochemistry and Molecular Medicine, University of California, Davis, California 95616.
Nahum SonenbergGoodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada.
Michael B MathewsDepartment of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey 07103.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein synthesis involves a complex machinery comprising numerous proteins and RNAs joined by noncovalent interactions. Its function is to link long chains of amino acids into proteins with precise sequences as encoded by the genome. Regulation of protein synthesis, called translational control, occurs both at a global level and at specific messenger RNAs (mRNAs). To understand how translation is regulated, knowledge of the molecular structures and kinetic interactions of its components is needed. This review focuses on the targets of translational control and the mechanisms employed.

Indexed as

Gene Expression RegulationGenomeProtein Biosynthesis5' Untranslated RegionsCodonCytoplasmKineticsPhosphorylationProtein ConformationProtein Processing, Post-TranslationalProteinsRibosomesRNARNA, Messenger5' Untranslated RegionsCodonProteinsRNARNA, Messenger

Identifiers

PMID29959195
PMCPMC6719596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.