ArticleArchives of biochemistry and biophysics2018
Intestinal β-carotene bioconversion in humans is determined by a new single-sample, plasma isotope ratio method and compared with traditional and modified area-under-the-curve methods.
Article in Archives of biochemistry and biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 16 citations in OpenAlex.
- Bioconversion of β-carotene to vitamin A across life stages using stable isotope methodologies: a protocol for the systematic review.Systematic reviews · 2026Article
- Novel Spectrophotometric Method for Robust Detection of Trace Copper and Cobalt in High-Concentration Zinc Solution.Molecules (Basel, Switzerland) · 2024Article
- A Spectral Detection Method Based on Integrated and Partition Modeling for Trace Copper in High-Concentration Zinc Solution.Molecules (Basel, Switzerland) · 2024Article
- Scientific opinion on the tolerable upper intake level for preformed vitamin A and β-carotene.EFSA journal. European Food Safety Authority · 2024Article
- Application of neural network adaptive filter method to simultaneous detection of polymetallic ions based on ultraviolet-visible spectroscopy.Frontiers in chemistry · 2024Article
- Article
- Vitamin A Requirements in Pregnancy and Lactation.Current developments in nutrition · 2020Review
- Vitamin A Absorption Efficiency Determined by Compartmental Analysis of Postprandial Plasma Retinyl Ester Kinetics in Theoretical Humans.The Journal of nutrition · 2020Article
- Vitamin A Absorption Determined in Rats Using a Plasma Isotope Ratio Method.The Journal of nutrition · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The vitamin A value (bioefficacy) of provitamin A carotenoids is determined by absorption of the carotenoid (bioavailability) and its subsequent conversion to retinol (bioconversion). Here we show that intestinal bioconversion of β-carotene can be estimated based on analysis of a single plasma sample collected 6 h after subjects ingest a test dose of stable isotope-labeled β-carotene from the ratio of retinyl esters to retinyl esters plus β-carotene. Plasma isotope ratio predictions of bioconversion ranged from 50 to- 93% (mean 76%) for 45 healthy young adults with low vitamin A stores. Results were the same as predictions made by a traditional area-under-the-curve method calculated from 0 to- 8 h or a modified area-under-the-curve method calculated from 0 to- 12 h. The modified method may provide better estimates of bioconversion between 8 and 24 h after ingestion of a carotenoid dose when stable isotopes cannot be used due to cost or logistics. Furthermore, because the plasma isotope ratio method requires only one blood sample and no isolation of triglyceride-rich lipoproteins, its use will facilitate estimation of provitamin A carotenoid bioconversion in human subjects and especially children, in whom repeated blood sampling is not feasible.
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