Evidence map›Paper›PMID 29958828›Full record

ArticleJournal of molecular and cellular cardiology2018

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

Sergiy M Nadtochiy, Yves T Wang, Keith Nehrke, Josh Munger, Paul S Brookes

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. NADMetabolites · 2025
    Article
  3. Review
  4. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
  5. Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. The Role of NADCurrent pharmaceutical biotechnology · 2024
    Article
  11. Review
  12. The cardioprotective role of sirtuins is mediated in part by regulating KAmerican journal of physiology. Cell physiology · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Harnessing NADCurrent heart failure reports · 2022
    Review
  17. Review
  18. Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Review
  19. Regulation of NADMetabolism: clinical and experimental · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sergiy M NadtochiyDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, USA; Department of Neuroscience, University of Rochester Medical Center, USA.
Yves T WangDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, USA.
Keith NehrkePharmacology and Physiology, University of Rochester Medical Center, USA; Department of Medicine, University of Rochester Medical Center, USA.
Josh MungerDepartment of Biochemistry, University of Rochester Medical Center, USA.
Paul S BrookesDepartment of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, USA; Pharmacology and Physiology, University of Rochester Medical Center, USA. Electronic address: paul_brookes@urmc.rochester.edu.
University of Rochester Medical Center · US

Funding

SIRT1, Nitro-Lipids and CardioprotectionR01HL071158 · NHLBI · UNIVERSITY OF ROCHESTER · PI BROOKES, PAUL S · 2003 to 2025
$7.7M
The Role of the Mitochondrial UPR in Ischemic ProtectionR01HL127891 · NHLBI · UNIVERSITY OF ROCHESTER · PI BROOKES, PAUL S, NEHRKE, KEITH · 2015 to 2018
$2.5M
HCMV-mediated repurposing of AMPK & CaMKK signaling for productive infectionR01AI127370 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2016 to 2020
$1.9M
NHLBI NIH HHS R01 HL071158NHLBI NIH HHS R01 HL127891NIAID NIH HHS R01 AI127370
6 · The paper itself

Abstract

Stimulation of the cytosolic NAD

Indexed as

AcidosisAcidsAdenosine TriphosphateAnimalsCardiotonic AgentsGlucoseGlycolysisHumansHydrogen-Ion ConcentrationMiceMyocardiumMyocytes, CardiacNADNaphthalenesNicotinamide MononucleotidePyronesAcidsAdenosine TriphosphateCardiotonic AgentsGlucoseNADNaphthalenesNicotinamide MononucleotidePyronesSirtuin 1Sirtuin 3splitomicinAcidosisGlycolysisIschemiaLactateNAD(+)NMN

Identifiers

PMID29958828
PMCPMC6103815
OpenAlexW2810605473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.