Evidence map›Paper›PMID 29958693›Full record

ArticleJournal of neuroimmunology2018

Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice.

Roger N Rosenberg, Min Fu, Doris Lambracht-Washington

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roger N RosenbergDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center Dallas, USA.
Min FuDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center Dallas, USA.
Doris Lambracht-WashingtonDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center Dallas, USA. Electronic address: doris.lambracht-washington@utsouthwestern.edu.

Funding

ROLE OF GLUTAMATE IN ALZHEIMER'S DISEASEP30AG012300 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI ROSENBERG, ROGER NEWMAN · 1994 to 2016
$26.6M
NIA NIH HHS P30 AG012300
6 · The paper itself

Abstract

Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1-42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1-42 immunization delivered via electroporation has potential to be used in the clinical setting.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAntibody FormationBiolisticsDose-Response Relationship, ImmunologicElectromagnetic PhenomenaElectroporationForkhead Transcription FactorsGenes, ReporterHumansImmunizationImmunogenicity, VaccineInjections, IntradermalMiceMice, Inbred BALB CAmyloid beta-Peptidesamyloid beta-protein (1-42)Forkhead Transcription FactorsFoxp3 protein, mousePeptide FragmentsVaccines, DNAAlzheimer's diseaseDNA Aβ42 immunotherapyDNA vaccinationElectroporationIgG isotypesImmune responseIntradermal immunizationNon-inflammatoryPulse parameter

Identifiers

PMID29958693
PMCPMC6192700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.