Evidence map›Paper›PMID 29958443›Full record

ReviewViruses2018

Tick-Borne Encephalitis Virus: A Structural View.

Lauri I A Pulkkinen, Sarah J Butcher, Maria Anastasina

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Tick-Borne Encephalitis (TBE): From Tick to Pathology.Journal of clinical medicine · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Viral subversion of the cell polarity regulator Scribble.Biochemical Society transactions · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lauri I A PulkkinenHiLIFE-Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. lauri.ia.pulkkinen@helsinki.fi.ORCID 0000-0002-3919-2498
Sarah J ButcherHiLIFE-Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. sarah.butcher@helsinki.fi.ORCID 0000-0001-7060-5871
Maria AnastasinaHiLIFE-Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland. maria.anastasina@helsinki.fi.ORCID 0000-0002-4555-6446
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts.

Indexed as

AnimalsEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneGenome, ViralGenomicsHumansLife Cycle StagesStructure-Activity RelationshipViral ProteinsVirus ReplicationViral Proteinsenvelope proteinE proteinflavivirus structurematurationM proteinnucleocapsidprMTBEVtick-borne encephalitis virusvirus assembly

Identifiers

PMID29958443
PMCPMC6071267
OpenAlexW2810256311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.