ReviewMolecules (Basel, Switzerland)2018
Cosmetics Preservation: A Review on Present Strategies.
Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878381 (Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream
Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- TFOS Lifestyle: Impact of cosmetics on the ocular surface.The ocular surface · 2023Pooled it
- A pilot study on the cutaneous effects of ethanol in a moisturizing cream on non-lesional skin of patients with atopic dermatitis.Scientific reports · 2025Trial
- In-Store Cosmetic Testers Harbour Resistant Bacteria: A Pilot Survey of Microbial Contamination and Antimicrobial Susceptibility in Portuguese Pharmacies.Microorganisms · 2026Article
- Characteristics of Biodegradable Car Shampoos in Terms of Performance and Environmental Properties.International journal of molecular sciences · 2026Article
- From Fundamental Self-Assembly Studies to Applications in Everyday Life: The Formation of a Supramolecular Shampoo.Gels (Basel, Switzerland) · 2026Article
- EDTA suppresses bacterial perseverance to 2-phenoxyethanol.Microbiology spectrum · 2026Article
- Study of contaminants in natural cosmetics.International journal of occupational medicine and environmental health · 2026Article
- Marine Rhodobacterales as Drivers of Ulva Growth: From Macroalgal-Bacterial Interactions to Bioactive Factor Enrichment.Journal of chemical ecology · 2026Article
- Preservatives in Leave-On Cosmetics Available on the Dutch Market.Contact dermatitis · 2026Article
- Bacterial Contamination and Antimicrobial Resistance in Used Eye Cosmetic Products.Microorganisms · 2026Article
- Exploring the anti-quorum sensing potential of synthetic lipstick dyes againstNew microbes and new infections · 2026Article
- Development and Physicochemical Characterisation of Probiotic Emulsions ContainingPharmaceutics · 2026Article
- Gallic Acid: A Potent Antioxidant and Anti-inflammatory Agent in Modern Cosmeceuticals.Recent advances in drug delivery and formulation · 2026Review
- Microbial contamination of medicines, medical devices, cosmetics, child and personal care products: a comprehensive review of secondary contamination risks in home-use settings.Frontiers in microbiology · 2026Review
- Mechanistic Insights into Flavonoids in Cosmetic Applications: Multifunctional Roles and Formulation Considerations.Clinical, cosmetic and investigational dermatology · 2026Review
- Review
- Spray-Dried Microcapsules of Lavandin (Molecules (Basel, Switzerland) · 2025Article
- Why ignore expiry dates on cosmetics? A qualitative study of perceived risk and its implications for cosmetics producers and regulators.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- A Live Bacterial Screening Assay for Membrane-Active Antimicrobial Compounds Using Imaging Fluorescence Correlation Spectroscopy.Analytical chemistry · 2025Article
- Cleansing Mechanisms and Efficacy on Artificial Skin.Molecules (Basel, Switzerland) · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cosmetics, like any product containing water and organic/inorganic compounds, require preservation against microbial contamination to guarantee consumer’s safety and to increase their shelf-life. The microbiological safety has as main goal of consumer protection against potentially pathogenic microorganisms, together with the product’s preservation resulting from biological and physicochemical deterioration. This is ensured by chemical, physical, or physicochemical strategies. The most common strategy is based on the application of antimicrobial agents, either by using synthetic or natural compounds, or even multifunctional ingredients. Current validation of a preservation system follow the application of good manufacturing practices (GMPs), the control of the raw material, and the verification of the preservative effect by suitable methodologies, including the challenge test. Among the preservatives described in the positive lists of regulations, there are parabens, isothiasolinone, organic acids, formaldehyde releasers, triclosan, and chlorhexidine. These chemical agents have different mechanisms of antimicrobial action, depending on their chemical structure and functional group’s reactivity. Preservatives act on several cell targets; however, they might present toxic effects to the consumer. Indeed, their use at high concentrations is more effective from the preservation viewpoint being, however, toxic for the consumer, whereas at low concentrations microbial resistance can develop.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.