ReviewChildren (Basel, Switzerland)2018
Current State of Pediatric Heart Failure.
Review in Children (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dose Rationale for Dapagliflozin and Empagliflozin in Paediatric Heart Failure: a Phase II.a Pharmacokinetics, Ease-of-swallow, Safety and Proof-of-concept Study Among Children 6-18 Years of Age
Repurposing Empagliflozin for Duchenne Muscular Dystrophy - Associated Cardiomyopathy: a Pharmacokinetics, Safety and Proof-of-concept Study Among Children 6-18 Years of Age
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Technology landscape of pediatric mechanical circulatory support devices: A systematic review 2010-2021.Artificial organs · 2022Pooled it
- Complications in children with ventricular assist devices: systematic review and meta-analyses.Heart failure reviews · 2022Pooled it
- Association between NT-proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA-HF and PARADIGM-HF.ESC heart failure · 2025Trial
- An Adult Population Pharmacokinetic Model to Simulate Subcutaneous Administration of a Fixed Dose of Furosemide in Adolescents with Heart Failure and Volume Overload.Clinical pharmacokinetics · 2025Trial
- Baseline Characteristics of Pediatric Patients With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction in the PANORAMA-HF Trial.Circulation. Heart failure · 2023Trial
- Relative Bioavailability of Omecamtiv Mecarbil Pediatric Minitablet Formulations in Healthy Adult Subjects.Clinical drug investigation · 2021Trial
- Clinical and Echocardiographic Determinants of Moderate Heart Failure in Children with Acyanotic Congenital Heart Disease: A Retrospective Single-Center Exploratory Prediction Modelling Study.Children (Basel, Switzerland) · 2026Article
- Predicting Cardiac Magnetic Resonance-Derived Ejection Fraction from Echocardiogram Via Deep Learning Approach in Tetralogy of Fallot.Pediatric cardiology · 2026Article
- Pediatric heart failure in the era of cardio-immunology: inflammatory-immune context phenotypes, diagnosis, and targeted management.Frontiers in immunology · 2026Review
- Basal-Predominant Right-Ventricular Dysfunction in Pediatric Dilated Cardiomyopathy: An Integrated Biventricular Strain Analysis.Biomedicines · 2025Article
- Left Atrial Deformation in Paediatric Dilated and Hypertrophic Cardiomyopathy: Insights from Two-Dimensional Speckle-Tracking Echocardiography.Journal of clinical medicine · 2025Article
- Machine Learning Reveals Novel Pediatric Heart Failure Phenotypes with Distinct Mortality and Hospitalization Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Pediatric Heart Failure Pharmacotherapy: Transformative Insights for the Future.Reviews in cardiovascular medicine · 2025Review
- Global Longitudinal Strain as a Sensitive Marker of Left Ventricular Dysfunction in Pediatric Dilated Cardiomyopathy: A Case-Control Study.Journal of cardiovascular development and disease · 2025Article
- Mechanical and Hemocompatibility Assessment of Selected Technologies for Prosthesis Connection with the Outflow Cannula Graft of the RH PEDJournal of clinical medicine · 2025Article
- Advancement of the Dragon Heart 7-Series for Pediatric Patients With Heart Failure.Artificial organs · 2025Article
- Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Home Milrinone Therapy for Paediatric Advanced Heart Failure Patients: A Canadian Single-Centre Experience.CJC pediatric and congenital heart disease · 2025Article
- Geospatial disparities in pediatric heart failure care in China: a multicenter cohort study.Frontiers in public health · 2025Article
- The Incidence of Heart Failure in Children with Congenital Heart Disease: A Prospective Cohort Study.Current cardiology reviews · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric heart failure (HF) represents an important cause of morbidity and mortality in childhood. There is an overlapping relationship of HF, congenital heart disease, and cardiomyopathy. The goal of treatment of HF in children is to maintain stability, prevent progression, and provide a reasonable milieu to allow somatic growth and optimal development. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. There are significant barriers in applying adult data to children because of developmental factors, age variation from birth to adolescence, and differences in the genetic expression profile and β-adrenergic signaling. At the same time, there are significant challenges in performing well-designed drug trials in children with HF because of heterogeneity of diagnoses identifying a clinically relevant outcome with a high event rate, and a difficulty in achieving sufficient enrollment. A judicious balance between extrapolation from adult HF guidelines and the development of child-specific data on treatment represent a wise approach to optimize pediatric HF management. This approach is helpful as reflected by the increasing role of ventricular assist devices in the management of advanced HF in children. This review discusses the causes, epidemiology, pathophysiology, clinical manifestations, conventional medical treatment, clinical trials, and the role of device therapy in pediatric HF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.