Evidence map›Paper›PMID 29958127›Full record

Trial reportDrug and alcohol dependence2018

Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial.

David J Moore, Elizabeth C Pasipanodya, Anya Umlauf, Alexandra S Rooney, Ben Gouaux, Colin A Depp, J Hampton Atkinson, Jessica L Montoya

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01317277 (Personalized Text Messages to Improve ART Adherence in HIV+ Methamphetamine Users), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01317277 nacompletednot on this map

Personalized Text Messages to Improve ART Adherence in HIV+ Methamphetamine Users

TypeinterventionalSponsorUniversity of California, San DiegoRan2011 to 2014Enrolled75ConditionsHIV, AIDSArmsindividualized Texting for Adherence Building (iTAB), Psychoeducation
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David J MooreDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA. Electronic address: djmoore@ucsd.edu.
Elizabeth C PasipanodyaDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Anya UmlaufDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Alexandra S RooneyDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Ben GouauxDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Colin A DeppDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
J Hampton AtkinsonDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Jessica L MontoyaDepartment of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Personalized Text Messages to Improve ART Adherence in HIV+ Methamphetamine UsersR34DA031058 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, DAVID J · 2011 to 2013
$686k
NIDA NIH HHS P50 DA026306NIDA NIH HHS R34 DA031058NIDA NIH HHS T32 DA031098NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

backgroundMethamphetamine (METH) use poses a barrier to antiretroviral therapy (ART) adherence. We evaluated the efficacy of the individualized texting for adherence building (iTAB) intervention among persons living with HIV (PLWH) who meet criteria for METH use disorder. We examined daily associations between ART adherence and text-reported METH use and depressed mood.

methodsWe conducted a single site, 2-arm, 6-week, pilot randomized clinical trial comparing a personalized, bidirectional, text messaging system (iTAB; n = 50) to an active control condition (n = 25). All participants received adherence psychoeducation and daily texts assessing METH use and depressed mood. The iTAB group received personalized daily ART reminder texts. ART adherence was monitored using Medication Event Monitoring System (MEMS) caps.

resultsResponse rates to daily ART reminder texts were high (79%), with good concordance between MEMS-derived and text-reported ART adherence (p < .001). Intervention groups did not differ in MEMS-derived ART adherence (68% iTAB, 70% active control; p = .68); however, participants in the iTAB group had fewer METH use days (median 14.4 iTAB, 22.0 active control; p = .05). Text-reported METH use, but not depressed mood, was associated with poorer MEMS-derived ART adherence.

conclusionsHigh text response rates and good concordance between MEMS-derived and text-reported adherence suggests text messaging is a feasible intervention delivery approach that provides a valid indication of ART adherence. Reductions in METH use among iTAB participants suggest daily health reminders may help attenuate substance use. Further research is needed to substantiate daily text messaging as a harm reduction approach.

Indexed as

AdultAmphetamine-Related DisordersAnti-HIV AgentsFemaleHIV InfectionsHumansMaleMedication AdherenceMethamphetamineMiddle AgedPilot ProjectsPrecision MedicineReminder SystemsText MessagingYoung AdultAnti-HIV AgentsMethamphetamineBehavior modificationHIV/AIDSMedication adherenceMethamphetaminemHealthStimulant

Identifiers

PMID29958127
PMCPMC6324532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.