Lean on Me: Cell-Cell Interactions Release TGF-β for Local Consumption Only.

Aidan J Peterson, Michael B O'Connor

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.1field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

In Vitro Analysis of PMEPA1 Upregulation in Mesenchymal Stem Cells Induced by Prostate Cancer Cells.International journal of molecular sciences · 2025
Article
Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice.Nature communications · 2024
Article
Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain.bioRxiv : the preprint server for biology · 2023
Article
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics.PLoS biology · 2019
Article

4 · The record

Corrections and comments

Comment on
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.2018

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aidan J PetersonDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Michael B O'ConnorDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: moconnor@umn.edu.

University of Minnesota · US

Funding

Inter-organ signals regulating metabolism, physiology and developmental timingR35GM118029 · NIGMS · UNIVERSITY OF MINNESOTA · PI O'CONNOR, MICHAEL BRENDAN · 2016 to 2025

$3.8M

NIGMS NIH HHS R35 GM118029

6 · The paper itself

Abstract

A new study combines detailed biochemical characterization with whole-animal genetics and computational transcriptome data mining to reveal how the LRRC33 milieu molecule imposes an exquisite level of spatial control on TGF-β signaling in the CNS.

Indexed as

AnimalsCell CommunicationMicrogliaSignal TransductionTranscriptomeTransforming Growth Factor betaTransforming Growth Factor beta

Identifiers

PMID29958107

DOI10.1016/j.cell.2018.06.008

OpenAlexW2811262768

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.