Evidence map›Paper›PMID 29957333›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2018

The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.

Shogo Furutani, Makoto Ihara, Kristin Lees, Steven D Buckingham, Frederick A Partridge, Jonathan A David, Rohit Patel, Scott Warchal, Ian R Mellor, Kazuhiko Matsuda and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Shogo FurutaniDepartment of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan.
Makoto IharaDepartment of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan.
Kristin LeesNeurosystems Section, Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Steven D BuckinghamCentre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
Frederick A PartridgeNeurosystems Section, Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK; Centre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK.
Jonathan A DavidSchool of Biology, University of St Andrews, North Haug, St. Andrews, Fife, Scotland KY16 9ST, UK.
Rohit PatelNeurosystems Section, Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK; School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Scott WarchalNeurosystems Section, Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Ian R MellorSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Kazuhiko MatsudaDepartment of Applied Biological Chemistry, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan.
David B SattelleNeurosystems Section, Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK; Centre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK. Electronic address: d.sattelle@ucl.ac.uk.
University of Manchester · GBKindai University · JPUniversity of Nottingham · GBUniversity College London · GBUniversity of St Andrews · GB

Funding

Medical Research Council
6 · The paper itself

Abstract

A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixodes scapularis, which transmits multiple pathogens including the agents of Lyme disease and human granulocytic anaplasmosis. When mRNA encoding IscaGluCl1 was expressed in Xenopus laevis oocytes, we detected robust 50-400 nA currents in response to 100 μM L-glutamate. Responses to L-glutamate were concentration-dependent (pEC

Indexed as

AbelmoschusAcaricidesAnimalsAzetidinesAzocinesChloride ChannelsDisease VectorsDrug DiscoveryGlutamic AcidIndole AlkaloidsIvermectinIxodesLyme DiseaseOocytesPenicilliumXenopus laevisAcaricidesAzetidinesAzocinesChloride Channelsglutamate-gated chloride channelsGlutamic AcidIndole AlkaloidsIvermectinokaramine BAcaricideGlutamate-gated chloride channelIvermectinOkaramine BTick Ixodes scapularis

Identifiers

PMID29957333
PMCPMC6039357
OpenAlexW2805829367

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.