Evidence map›Paper›PMID 29957251›Full record

ArticleInternational journal of cardiology2018

Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study.

Claire A Lawson, J M Testani, M Mamas, K Damman, P W Jones, L Teece, U T Kadam

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Claire A LawsonLeicester Diabetes Centre, Leicester University, UK; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, University of Keele, Stoke-on-Trent, UK. Electronic address: cl417@leicester.ac.uk.
J M TestaniYale University, New Haven, CT, United States.
M MamasKeele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, University of Keele, Stoke-on-Trent, UK.
K DammanUniversity of Groningen, University Medical Center, Groningen, The Netherlands.
P W JonesFaculty of Medicine and Health Sciences, Keele University, England, UK.
L TeeceFaculty of Medicine and Health Sciences, Keele University, England, UK.
U T KadamLeicester Diabetes Centre, Leicester University, UK; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, University of Keele, Stoke-on-Trent, UK.
Keele University · GBUniversity of Leicester · GBUniversity Medical Center Groningen · NLYale University · US

Funding

Department of Health DRF-2012-05-288
6 · The paper itself

Abstract

backgroundRoutine heart failure (HF) monitoring and management is in the community but the natural course of worsening renal function (WRF) and its influence on HF prognosis is unknown. We investigated the influence of routinely monitored renal decline and related comorbidities on imminent hospitalisation and death in the HF community population.

methodsA nested case-control study within an incident HF cohort (N = 50,114) with 12-years follow-up. WRF over 6-months before first hospitalisation and 12-months before death was defined by >20% reduction in estimated glomerular filtration rate (eGFR). Additive interactions between chronic kidney disease (CKD) and comorbidities were investigated.

resultsPrevalence of CKD (eGFR<60 ml/min/1.73m

conclusionsIn HF, the risk associated with CKD differs between the community and the acute HF setting. In the community setting, moderate CKD confers no risk but severe CKD, WRF or CKD with other comorbidities identifies patients at high risk of imminent hospitalisation and death.

Indexed as

Heart FailureRenal Insufficiency, ChronicAgedCase-Control StudiesComorbidityDisease ProgressionFemaleGlomerular Filtration RateHospitalizationHumansMaleMiddle AgedPatient Care ManagementPrevalencePrognosisRisk FactorsChronic kidney diseaseComorbidityDeathHeart failureHospitalisationPopulation basedWorsening renal function

Identifiers

PMID29957251
PMCPMC6024224
OpenAlexW2809828639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.