ArticleMolecular medicine reports2018
Application of 460 nm visible light for the elimination of Candida albicans in vitro and in vivo.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- A Collection and Analysis of Simplified Data for a Better Understanding of the Complex Process of Biofilm Inactivation by Ultraviolet and Visible Irradiation.Microorganisms · 2025Review
- Article
- Different essential oils can inhibit Candida albicans biofilm formation on acrylic resin by suppressing aspartic proteinase: In vitro and in silico approaches.Clinical oral investigations · 2025Article
- Electromagnetic Modulation of Cell Behavior: Unraveling the Positive Impacts in a Comprehensive Review.Annals of biomedical engineering · 2024Review
- Fungal photoinactivation doses for UV radiation and visible light-a data collection.AIMS microbiology · 2024Review
- Photoinactivation of Yeast and Biofilm Communities ofJournal of fungi (Basel, Switzerland) · 2022Article
- Microbial Photoinactivation by Visible Light Results in Limited Loss of Membrane Integrity.Antibiotics (Basel, Switzerland) · 2021Article
- Article
- Effect of Different Wavelengths of Laser Irradiation on the Skin Cells.International journal of molecular sciences · 2021Review
- Visible Lights Combined with Photosensitizing Compounds Are Effective against Candida albicans Biofilms.Microorganisms · 2021Article
- Photodynamic Therapy Is Effective AgainstFrontiers in cellular and infection microbiology · 2021Article
- Recent Advances in Non-Conventional Antimicrobial Approaches for Chronic Wound Biofilms: Have We Found the 'Chink in the Armor'?Biomedicines · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the eradicating effects of 460 nm blue light (BL) on Candida albicans in vitro and in C. albicans‑infected skin wounds in a mouse model. In the present study, the antifungal effects of irradiation with BL on C. albicans in vitro and in vivo were investigated. C. albicans colonies and cell numbers were investigated using the spread plate method and flow cytometry respectively following treatment with BL irradiation. In order to determine whether BL can eradicate C. albicans cells within biofilms, an in vitro C. albicans biofilm model was established, and the effect of BL was subsequently investigated using a confocal laser scanning microscope and a Live/Dead staining kit. Furthermore, a mouse skin wound infection model infected with C. albicans was established. Wound healing rates and histological examinations were determined 0, 3, 7, 10 and 14 days post‑wounding. The results revealed that C. albicans was eradicated by BL in a dose‑dependent manner, with a minimum fluence of 60 J/cm2. Irradiation with BL almost completely eradicated C. albicans when the light fluence was 240 J/cm2. C. albicans inside biofilms was also eradicated and biofilms were destroyed following BL irradiation at 240 J/cm2. In addition, BL was revealed to significantly suppress C. albicans infection in vivo. Irradiation with BL promoted the wound healing of C. albicans infected‑skin wounds in a mouse model. In conclusion, the results of the present study demonstrated that 460 nm BL may eradicate planktonic and biofilm C. albicans in vitro, and represents a novel therapeutic strategy for the treatment of C. albicans infections in vivo.
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