ArticleMolecular medicine reports2018
Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
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- The Dual Role of Perivascular Adipose Tissue in Vascular Homeostasis and Atherogenesis: From Physiology to Pathological Implications.International journal of molecular sciences · 2025Review
- Skeletal muscle endothelial dysfunction through the activin A-PGC1α axis drives progression of cancer cachexia.Nature cancer · 2025Article
- A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease.Journal of the American Society of Nephrology : JASN · 2024Article
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- The effect of miR-223-3p on endothelial cells in coronary artery disease.In vitro cellular & developmental biology. Animal · 2024Article
- KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.Molecular biotechnology · 2024Article
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.Frontiers in neurology · 2024Article
- The Beneficial Effects of Pine Nuts and Its Major Fatty Acid, Pinolenic Acid, on Inflammation and Metabolic Perturbations in Inflammatory Disorders.International journal of molecular sciences · 2023Review
- Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling.Cell stress & chaperones · 2023Article
- Pinolenic acid exhibits anti-inflammatory and anti-atherogenic effects in peripheral blood-derived monocytes from patients with rheumatoid arthritis.Scientific reports · 2022Article
- Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment.Nano research · 2022Article
- PA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes.Nutrition & metabolism · 2021Article
- Expressions and relationship of Krüppel-like factor 15 and endothelial nitric oxide synthase in experimental deep venous thrombosis.Annals of translational medicine · 2020Article
- Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model.International journal of molecular medicine · 2020Article
- Article
- Effects of compound lobelia oral liquid on acute pharyngitis rabbits model.Saudi journal of biological sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis (AS) is a cardiovascular disease with a relatively high incidence rate. Krüppel‑like factor 15 (KLF15) has a role in numerous pathological processes, including nephropathy, abnormal glucose metabolism and myocardial injury. The aim of the present study was to investigate the function of KLF15 in vascular endothelial dysfunction. MTT analyses, nitric oxide (NO) detection and cell adhesion detection kits were used to investigate the viability and adhesion of, and quantity of NO released by Eahy926 cells induced by tumor necrosis factor (TNF)‑α, respectively. Reverse transcription‑quantitative polymerase chain reaction and western blot analyses were performed to determine the expression levels of KLF15, endothelial nitric oxide synthase, monocyte chemoattractant protein‑1 (MCP‑1), intercellular adhesion molecule‑1 (ICAM‑1), transforming growth factor‑β1 (TGF‑β1), phosphorylated (p‑)transcription factor p65 (p65) and nuclear factor erythroid 2‑related factor 2 (Nrf2). The results of the present study demonstrated that TNF‑α was able to induce vascular endothelial dysfunction in Eahy926 cells at an optimum concentration of 10 ng/ml. Overexpression of KLF15 markedly enhanced cell viability in addition to the quantity of released NO of TNF‑α‑induced Eahy926 cells, and increased the expression levels of eNOS and Nrf2. Furthermore, overexpression of KLF15 markedly suppressed the rate of cellular adhesion, and downregulated levels of MCP‑1, ICAM‑1, TGF‑β1 and p‑p65 in TNF‑α induced Eahy926 cells. In conclusion, the results of the present study suggested that overexpression of KLF15 in Eahy926 cells exhibited a protective effect against TNF‑α induced dysfunction via activation of Nrf2 signaling and inhibition of nuclear factor κB signaling.
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