ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Genetic susceptibility for celiac disease is highly prevalent in the Saudi population.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease.International journal of molecular sciences · 2023Pooled it
- Celiac disease in type 1 diabetes mellitus in the Kingdom of Saudi Arabia. Characterization and meta-analysis.Saudi medical journal · 2019Pooled it
- Celiac disease among at-risk individuals in Saudi Arabia.Saudi medical journal · 2019Pooled it
- Combined ProbioticMolecules (Basel, Switzerland) · 2026Trial
- Prevalence of Autoimmune Thyroid Disease among Individuals with Celiac Disease in a Primary Care Setting in Riyadh, Saudi Arabia.Saudi medical journal · 2026Article
- Age as a Predictor of Serum Tumor Necrosis Factor Antagonist Drug and Antidrug Antibody Concentrations in Inflammatory Bowel Disease-A Nationwide Cohort Study.Journal of clinical medicine · 2025Article
- Gut microbiota predicts the diagnosis of celiac disease in Saudi children.World journal of gastroenterology · 2023Article
- Microbiota profile of new-onset celiac disease in children in Saudi Arabia.Gut pathogens · 2022Article
- Viral dysbiosis in children with new-onset celiac disease.PloS one · 2022Article
- TagSNP approach for HLA risk allele genotyping of Saudi celiac disease patients: effectiveness and pitfalls.Bioscience reports · 2021Article
- Article
- Whole exome sequencing of a Saudi family and systems biology analysis identifiesSaudi journal of biological sciences · 2020Article
- Celiac autoantibody positivity in relation to clinical characteristics in children with type 1 diabetes.Journal of clinical and translational research · 2020Article
- Review
- Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia.PloS one · 2020Article
- Frequency of HLA celiac disease risk alleles and haplotypes in healthy adults in Tamil Nadu.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Health related quality of life among Saudi children and adolescents with celiac disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Social media usage pattern and its influencing factors among celiac patients and their families.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- The puzzling relationship between human leukocyte antigen HLA genes and celiac disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimTo determine the frequency of celiac disease (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in the Saudi population, where the prevalence of CD is 1.5% as recently reported in a mass screening study. PATIENTS AND
methodsIn a cross-sectional population-based study, a total of 192 randomly selected healthy school children (97 females, mean age 10.5 ± 2.2 years, all negative for tissue transglutaminase-IgA) were typed for D QA1 and D QB1 genes by polymerase chain reaction sequence-specific oligonucleotide probes.
resultsOf the 192 children, 52.7% carried the high-risk CD-associated HLA-DQ molecules: homozygous DQ2.5 ( 2.6%), DQ2.5/DQ2.2 ( 4.7%), heterozygous DQ2.5 ( 28.15%), homozygous DQ8 ( 4.2%), DQ8/DQ2.2 ( 3.6%), and double dose DQ2.2 ( 9.4%). Low-risk CD-associated HLA-DQ molecules (single dose DQ2.2 and heterozygous DQ8) constituted 3.6% and 9.4%, respectively. Among the very low-risk groups, individuals lacking alleles that contribute to DQ2/DQ8 variants (33.5%), 13.5% carried only one of the alleles of the high-risk HLA-DQ2.5 heterodimer called "half-heterodimer" (HLA-DQA1*05 in 12% and HLA-DQB1* 02 in 1.5%), and 20.8% lacked all the susceptible alleles (DQX.x). Gender distribution was not significantly different among the CD-risk groups.
conclusionWe report one of the highest frequencies of CD-predisposing HLA-DQ genotypes among healthy general populations (52.7%) worldwide, which might partly explain the high prevalence of CD in the Saudi community.
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