Evidence map›Paper›PMID 29956686›Full record

SynthesisAsian journal of andrology

Risk of prostate cancer in men with spinal cord injury: A systematic review and meta-analysis.

Arcangelo Barbonetti, Settimio D'Andrea, Alessio Martorella, Giorgio Felzani, Sandro Francavilla, Felice Francavilla

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Race and Age-Related PSA Testing Disparities in Spinal Cord Injured Men: Analysis of National Veterans Health Administration Data.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arcangelo BarbonettiSpinal Unit, San Raffaele Sulmona Institute, Sulmona 67039, Italy.
Settimio D'AndreaAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
Alessio MartorellaAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
Giorgio FelzaniSpinal Unit, San Raffaele Sulmona Institute, Sulmona 67039, Italy.
Sandro FrancavillaAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
Felice FrancavillaAndrology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila 67100, Italy.
University of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A lower risk of prostate cancer has been reported in men with spinal cord injury (SCI) as compared to that observed in able-bodied subjects. As injury-related consequences can have opposite effects on prostate pathophysiology, this meta-analysis aimed to (1) establish the existence/quantify the extent of decreased prostate cancer risk following SCI and (2) find out if there is any statistically significant difference in prostate-specific antigen (PSA) levels between SCI and able-bodied subjects. MEDLINE, Cochrane Library, Scopus, CINAHL, and ScienceDirect databases were used. Only studies reporting a prostate cancer diagnosis and/or PSA levels following SCI and in able-bodied controls were included. Five studies provided information about prostate cancer on 35 293 subjects with SCI and 158 140 controls. Six studies were included in PSA analysis which reported information on 391 men with SCI and 1921 controls. Pooled estimates indicated that SCI reduced the prostate cancer risk by approximately 50% as compared to controls, whereas differences in PSA levels were not statistically significant. Funnel plots suggested the presence of publication bias only in PSA analysis. Between-study heterogeneity was established and when, according to meta-regression models, analysis was restricted to studies including men with mean age over 55 years, prostate cancer risk in SCI decreased up to 65.0% than that in controls with no heterogeneity (P = 0.33, I

Indexed as

AgedAged, 80 and overAge FactorsHumansMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsRiskSpinal Cord InjuriesProstate-Specific Antigenparaplegiaprostate cancerprostate-specific antigenquadriplegiaspinal cord injury

Identifiers

PMID29956686
PMCPMC6219305
OpenAlexW2810797820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.