Evidence map›Paper›PMID 29956461›Full record

ReviewJournal of cellular and molecular medicine2018

The regulatory role of microRNAs in angiogenesis-related diseases.

Li-Li Sun, Wen-Dong Li, Feng-Rui Lei, Xiao-Qiang Li

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
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  7. Therapeutic Potential of Modulating Gene-MicroRNA Crosstalk in Burn Injury.International journal of molecular sciences · 2025
    Review
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  16. A Narrative Review of Diabetic Macroangiopathy: From Molecular Mechanism to Therapeutic Approaches.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Review
  17. MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis and wound healing in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  18. Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Li-Li SunDepartment of Vascular Surgery, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.ORCID 0000-0003-3809-0374
Wen-Dong LiDepartment of Vascular Surgery, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.ORCID 0000-0001-8344-419X
Feng-Rui LeiDepartment of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0000-0001-5861-7239
Xiao-Qiang LiDepartment of Vascular Surgery, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.ORCID 0000-0001-5279-9158
Nanjing Drum Tower Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at a post-transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis-related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA-based biomarkers in the diagnosis, treatment and prognosis of angiogenesis-related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.

Indexed as

Angiogenesis Modulating AgentsApoptosisBiomarkersCardiovascular DiseasesCell DifferentiationCell MovementCell ProliferationEndothelial CellsEndothelium, VascularGene Expression RegulationHumansMicroRNAsMolecular Targeted TherapyNeovascularization, PathologicRNA, MessengerSignal TransductionAngiogenesis Modulating AgentsBiomarkersMicroRNAsRNA, MessengerangiogenesismicroRNAnon-coding RNAvascular disease

Identifiers

PMID29956461
PMCPMC6156236
OpenAlexW2811428863

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.