Evidence map›Paper›PMID 29956456›Full record

ArticleStress and health : journal of the International Society for the Investigation of Stress2018

The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis.

Joya N Hampton, Hanan D Trotman, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Daniel H Mathalon, Thomas H McGlashan, Ming T Tsuang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stress and health : journal of the International Society for the Investigation of Stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 2 countries.

Joya N HamptonEmory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9921-281X
Hanan D TrotmanMercer University, Macon, GA, USA.
Jean AddingtonUniversity of Calgary, Calgary, AB, Canada.
Carrie E BeardenUniversity of California, Los Angeles, Los Angeles, CA, USA.
Kristin S CadenheadUniversity of California, San Diego, San Diego, CA, USA.
Tyrone D CannonYale University, New Haven, CT, USA.
Barbara A CornblattHillside Hospital, Glen Oaks, NY, USA.
Daniel H MathalonUniversity of California, San Francisco, San Francisco, CA, USA.
Thomas H McGlashanYale University, New Haven, CT, USA.
Ming T TsuangUniversity of California, San Diego, San Diego, CA, USA.
Diana O PerkinsUniversity of North Carolina, Chapel Hill, Chapel Hill, NC, USA.
Larry J SeidmanBeth Israel Deaconess Medical Center, Boston, MA, USA.
Scott W WoodsYale University, New Haven, CT, USA.
Elaine F WalkerEmory University, Atlanta, GA, USA.
Yale University · USEmory University · USUniversity of California San Diego · USBeth Israel Deaconess Medical Center · USMercer University · USUniversity of Calgary · CAUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USZucker Hillside Hospital · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2003 to 2014
$18.6M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
Vulnerability to Progression SchizophreniaP50MH080272 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WOO, TSUNGUNG · 2007 to 2011
$9.9M
5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
Neurodevelopment and Psychosis in the 22q11.2 Deletion SyndromeR01MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2010 to 2020
$6.2M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
NCATS NIH HHS UL1 TR000170NIMH NIH HHS K24 MH076191NIMH NIH HHS P50 MH066286NIMH NIH HHS P50 MH080272NIMH NIH HHS R01 MH060720NIMH NIH HHS R01 MH085953NIMH NIH HHS R37 MH085953NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01MH081984NIMH NIH HHS U01 MH081988NIMH NIH HHS U01MH081988NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

Atypical antipsychotics (AT) and stress are related to weight gain in individuals with severe mental illness. This cross-sectional study examines AT use, stressful life events, and baseline weight in a sample of youth at clinical high risk for psychosis. Results showed that dependent and desirable life events moderated the relationship between AT use and weight after controlling for demographic factors and selective serotonin reuptake inhibitor antidepressant (AD) use. The relation of AD and weight was explored as a secondary analysis and showed no relation between AD use and weight. Further, stress did not moderate the relationship between AD medication and weight after controlling for antipsychotic use. Results suggest that stress exposure may exacerbate the relationship between ATs and increased weight in clinical high-risk populations. Findings have implications for the development of interventions to address psychosocial factors that worsen or buffer the adverse effects of antipsychotic medication on weight.

Indexed as

AdolescentAntipsychotic AgentsCross-Sectional StudiesFemaleHumansMalePsychotic DisordersStress, PsychologicalWeight GainYoung AdultAntipsychotic Agentsatypical antipsychoticsprodromestressweight

Identifiers

PMID29956456
PMCPMC6289596
OpenAlexW2810942070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.