ArticleBipolar disorders2019
Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.
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Article in Bipolar disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 37 citations in OpenAlex.
- The impact of collider bias on genetic prediction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Molecular Signatures of Early-Onset Bipolar Disorder and Schizophrenia: Transcriptomic and Machine-Learning Insights into Calcium and cAMP Signaling, Including Sex-Specific Patterns.International journal of molecular sciences · 2025Article
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models.Translational psychiatry · 2025Article
- Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring.Journal of affective disorders · 2025Article
- The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study.International journal of bipolar disorders · 2024Article
- Association between polarity of first episode and solar insolation in bipolar I disorder.Journal of psychosomatic research · 2022Article
- Characterisation of age and polarity at onset in bipolar disorder.The British journal of psychiatry : the journal of mental science · 2021Article
- Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.Nature communications · 2021Article
- Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder.International journal of bipolar disorders · 2021Article
- Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample.JAMA psychiatry · 2021Article
- [Neurogenetics of schizophrenia: findings from studies based on data sharing and global partnerships].Der Nervenarzt · 2021Review
- Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies.International journal of bipolar disorders · 2021Article
- CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations.Frontiers in psychiatry · 2020Article
- The genetic relationship between educational attainment and cognitive performance in major psychiatric disorders.Translational psychiatry · 2019Article
- Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.Bipolar disorders · 2019Article
- Treatment-Resistant Schizophrenia: Insights From Genetic Studies and Machine Learning Approaches.Frontiers in pharmacology · 2019Review
- Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder.Annals of medicineReview
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Authors and funding
143 authors at 20 institutions in 13 countries.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Heike Anderson-SchmidtInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Till Fm AndlauerMax Planck Institute of Psychiatry, Munich, Germany.
Ion-George AnghelescuPrivate Neuropathic Hospital Dr. med. Kurt Fontheim, Liebenburg, Germany.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasDepartament Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Volker AroltDepartment of Psychiatry, University of Münster, Münster, Germany.
Jean-Michel AubryMood Disorders Unit, Department of Psychiatry, HUG - Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
Kim BartholdiInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Michael BauerDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
Bernhard T BauneDiscipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
Thomas BeckerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Frank BellivierINSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
Antonio BenabarreBipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Susanne BengesserMedical University of Graz, Graz, Austria.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Joanna M BiernackaMayo Clinic, Rochester, MN, USA.
Armin BirnerMedical University of Graz, Graz, Austria.
Clara Brichant-PetitjeanINSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Pablo CervantesMood Disorders Program, McGill University Health Centre, Montreal, QC, Canada.
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Scott R ClarkDiscipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
Francesc ColomMental Health Program, IMIM (Hospital del Mar Medical Research Institute), CIBERSAM Barcelona, Catolonia, Spain.
Ashley L ComesInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Cristiana CruceanuMax Planck Institute of Psychiatry, Munich, Germany.
Piotr M CzerskiLaboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Alexandre DayerMood Disorders Unit, Department of Psychiatry, HUG - Geneva University Hospitals, Geneva, Switzerland.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Jay Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Detlef E DietrichAMEOS Clinical Center Hildesheim, Hildesheim, Germany.
Bruno ÉtainINSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
Thomas EthoferDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
Andreas FallgatterDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Christian FiggeKarl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
Laura FlatauInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Here FolkertsDepartment of Psychiatry, Psychotherapy and Psychosomatics, Clinical Center Wilhelmshaven, Wilhelmshaven, Germany.
Louise FrisenDepartment of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
Mark A FryeMayo Clinic, Rochester, MN, USA.
Janice M FullertonNeuroscience Research Australia, Sydney, NSW, Australia.
Katrin GadeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Sébastien GardCH Ch Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Anna GryaznovaInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Maria HakeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Joanna HauserLaboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Stefan HermsInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
Markus JägerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Stephane JamainINSERM U955 Equipe 15 - Psychiatrie Genetique, Hopital Henri Mondor, Creteil, Cedex, France.
Esther JiménezBipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Georg JuckelDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Layla KassemHuman Genetics Branch, Section on Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MD, USA.
John KelsoeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Sebastian KliwickiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Farah Klohn-SagatholislamInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Manfred KollerAsklepios Specialized Hospital, Göttingen, Germany.
Barbara KönigHospital Neunkirchen, Neunkirchen, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
Nina LacknerMedical University of Graz, Graz, Austria.
Gonzalo LajeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
Mikael LandénGothenburg University, Sahlgrenska Academy, Gothenburg, Sweden.
Fabian U LangDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Catharina LavebrattCH Ch Perrens, Bordeaux, France.
Marion LeboyerINSERM U955 Equipe 15 - Psychiatrie Genetique, Hopital Henri Mondor, Creteil, Cedex, France.
Susan G LeckbandDepartment of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.
Mario MajDepartment of Psychiatry, Campania University L. Vanvitelli, Naples, Italy.
Mirko ManchiaSection of Psychiatry, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Susan L McElroyLindner Center of HOPE, Research Institute, Mason, OH, USA.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Marina MitjansUnitat d'Antropologia (Dp. Biología Animal), Department of Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Palmiero MonteleoneDepartment of Psychiatry, Campania University L. Vanvitelli, Naples, Italy.
Vanessa NieratschkerDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Tomas NovákNational Institute of Mental Health, Klecany, Czech Republic.
Urban ÖsbyDepartment of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
James B PotashPsychiatry, University of Iowa, Iowa City, IA, USA.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Jens ReimerDepartment of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
Eva ReininghausMedical University of Graz, Graz, Austria.
Markus ReittDepartment of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
Stephan RipkeDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Guy A RouleauMood Disorders Program, McGill University Health Centre, Montreal, QC, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
Harald ScherkAMEOS Clinical Center Osnabrück, Osnabrück, Germany.
Max SchmaußDepartment of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW, Australia.
K Oliver SchubertDiscipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Sybille SchulzDepartment of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Christian SimhandlSigmund Freud University, Vienna, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Carsten SpitzerASKLEPIOS Specialized Hospital Tiefenbrunn, Rosdorf, Germany.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Sophia StegmaierDepartment of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
Sebastian StierlPsychiatric Hospital Lüneburg, Lüneburg, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czech Republic.
Andreas ThielDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
Sarah K TighePsychiatry, University of Iowa, Iowa City, IA, USA.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Gustavo TureckiDouglas Hospital, Verdun, QC, Canada.
Eduard VietaBipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Julia VeehDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Martin von HagenClinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
Moritz E WigandDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
Stephanie WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Adam WrightSchool of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Peter P ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Jörg ZimmermannDepartment of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
Markus NöthenInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEKarolinska Institutet · SEUniversity of California San Diego · USUniversity of Cagliari · ITUniversity of Göttingen · DEDalhousie University · CAMedical University of Graz · ATPoznan University of Medical Sciences · PLUniversität Ulm · DEUniversity of Tübingen · DECentro de Investigación Biomédica en Red de Salud Mental · ESInserm · FRKlinikum Bremen-Mitte · DELife & Brain (Germany) · DEMcGill University Health Centre · CAThe University of Adelaide · AUUniversity of Baltimore · USAgaplesion Diakonieklinikum Rotenburg · DECentral Institute of Mental Health · DECentre Hospitalier Charles Perrens · FR
Funding
Mapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2MIdentification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5MAbstract
objectivesBipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.
methodsA total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.
resultsBD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.
conclusionsThe current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
Indexed as
AdolescentAdultAge FactorsBipolar DisorderChildFemaleHumansMaleMiddle AgedMultifactorial InheritancePhenotypeSchizophreniaage at onsetbipolar disorderearly onsetpolygenic risk scoreschizophrenia
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