Evidence map›Paper›PMID 29956324›Full record

ArticleThe Journal of physiology2018

The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH.

Henriette L Christensen, Dagne Barbuskaite, Aleksandra Rojek, Hans Malte, Inga B Christensen, Annette C Füchtbauer, Ernst-Martin Füchtbauer, Tobias Wang, Jeppe Praetorius, Helle H Damkier

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Levetiracetam inhibits the NaActa physiologica (Oxford, England) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Cerebrospinal fluid pH regulation.Pflugers Archiv : European journal of physiology · 2024
    Review
  10. The role of NaPflugers Archiv : European journal of physiology · 2024
    Review
  11. Review
  12. NHFrontiers in physiology · 2024
    Article
  13. Article
  14. Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023
    Review
  15. The astrocytic NaThe Journal of physiology · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Alkalosis-induced hypoventilation in cystic fibrosis: The importance of efficient renal adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. A Splicing Mutation inInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Henriette L ChristensenDepartment of Biomedicine, Health, Aarhus University, Denmark.
Dagne BarbuskaiteDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Aleksandra RojekDepartment of Biomedicine, Health, Aarhus University, Denmark.
Hans MalteDepartment of Bioscience, Science and Technology, Aarhus University, Denmark.
Inga B ChristensenDepartment of Biomedicine, Health, Aarhus University, Denmark.
Annette C FüchtbauerDepartment of Molecular Biology and Genetics, Science and Technology, Aarhus University, Denmark.
Ernst-Martin FüchtbauerDepartment of Molecular Biology and Genetics, Science and Technology, Aarhus University, Denmark.
Tobias WangDepartment of Bioscience, Science and Technology, Aarhus University, Denmark.
Jeppe PraetoriusDepartment of Biomedicine, Health, Aarhus University, Denmark.
Helle H DamkierDepartment of Biomedicine, Health, Aarhus University, Denmark.ORCID 0000-0001-7518-4017
Aarhus University · DKUniversity of Copenhagen · DK

Funding

Aase og Ejnar Danielsens Fond N/AFaculty of Health, Aarhus UniversityFaculty of Health and Medical SciencesIndependent Research Foundation Denmark/Medical SciencesLaege Sofus Carl Emil Friis og Hustru Olga Friis´legatVera og Carl Johan Michaelsens Legat
6 · The paper itself

Abstract

key pointsNormal pH is crucial for proper functioning of the brain, and disorders increasing the level of CO ABSTRACT: The choroid plexus epithelium (CPE) is located in the brain ventricles where it produces the majority of the cerebrospinal fluid (CSF). The hypothesis that normal brain function is sustained by CPE-mediated CSF pH regulation by extrusion of acid-base equivalents was tested by determining the contribution of the electrogenic Na

Indexed as

Acidosis, RespiratoryAcute DiseaseAnimalsBicarbonatesCerebrospinal FluidChoroid PlexusHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMice, KnockoutSeizuresSodiumSodium-Bicarbonate SymportersBicarbonatesSLC4A5 protein, mouseSodiumSodium-Bicarbonate Symporterscerebrospinal fluidchoroid plexusNBCe2pH regulationrespiratory acidosis

Identifiers

PMID29956324
PMCPMC6166071
OpenAlexW2892221726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.