Evidence map›Paper›PMID 29956273›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Analysis of Progranulin-Mediated Akt and MAPK Activation.

Shi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonino Belfiore, Renato V Iozzo, Andrea Morrione

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Complexity of progranulin mechanisms of action in mesothelioma.Journal of experimental & clinical cancer research : CR · 2022
    Article
  4. Review
  5. Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer.Matrix biology : journal of the International Society for Matrix Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shi-Qiong XuBiology of Prostate Cancer Program, Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA.
Simone BuraschiCancer Cell Biology and Signaling Program, Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Ryuta TanimotoBiology of Prostate Cancer Program, Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA.
Manuela StefanelloBiology of Prostate Cancer Program, Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA.
Antonino BelfioreDepartment of Health and Endocrinology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Renato V IozzoCancer Cell Biology and Signaling Program, Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Andrea MorrioneBiology of Prostate Cancer Program, Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA. Andrea.Morrione@jefferson.edu.
Thomas Jefferson University · USMagna Graecia University · ITSidney Kimmel Cancer Center · US

Funding

Progranulin signaling in bladder cancerR01CA164462 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V., MORRIONE, ANDREA · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA164462
6 · The paper itself

Abstract

Progranulin has emerged in recent years as an important regulator of various biological functions including cell proliferation, wound healing, motility, and protection from apoptosis. Progranulin is also critical for transformation as established in several cancer models.Progranulin biological responses elicit through the activation of the Akt and MAPK pathways, which are critical for progranulin downstream signaling.In this chapter various experimental approaches aiming at detecting progranulin-mediated Akt and MAPK activation will be discussed.

Indexed as

AntibodiesBiochemistryEnzyme ActivationHumansImmunoblottingMAP Kinase Signaling SystemMitogen-Activated Protein KinasesPhosphorylationProgranulinsProto-Oncogene Proteins c-aktStaining and LabelingAntibodiesMitogen-Activated Protein KinasesProgranulinsProto-Oncogene Proteins c-aktAktConfocal analysisElectrophoresisImmunofluorescenceMAP kinaseNitrocellulose membranePathScanProgranulinSDS PAGE

Identifiers

PMID29956273
PMCPMC9186102
OpenAlexW2810428965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.