Evidence map›Paper›PMID 29956088›Full record

SynthesisJournal of molecular neuroscience : MN2018

Postmortem Brain, Cerebrospinal Fluid, and Blood Neurotrophic Factor Levels in Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Yang Du, Huan-Tong Wu, Xiao-Yan Qin, Chang Cao, Yi Liu, Zong-Ze Cao, Yong Cheng

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yang DuCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Huan-Tong WuCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Xiao-Yan QinCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Chang CaoCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Yi LiuCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Zong-Ze CaoCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China.
Yong ChengCenter on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, 27 South Zhongguancun Avenue, Beijing, 100081, China. yongcheng@muc.edu.cn.ORCID http://orcid.org/0000-0002-7529-4408
Minzu University of China · CN

Funding

National Natural Science Foundation of China 81703492Natural Science Foundation of Beijing Municipality 7182092
6 · The paper itself

Abstract

Accumulating evidence suggest that aberrations of neurotrophic factors are involved in the etiology and pathogenesis of Alzheimer's disease (AD), but clinical data were inconsistent. Therefore, a meta-analysis on neurotrophic factor levels in AD is necessary. We performed a systematic review of blood, CSF, and post-mortem brain neurotrophic factor levels in patients with AD compared with controls and quantitatively summarized the clinical data in blood and CSF with a meta-analytical technique. A systematic search of PubMed and Web of Science identified 98 articles in this study (with samples more than 9000). Random effects meta-analysis demonstrated that peripheral blood BDNF levels were significantly decreased in AD patients compared with controls. However, blood NGF, IGF, and VEGF did not show significant differences between cases and controls. In CSF, random effects meta-analysis showed significantly deceased BDNF and increased NGF levels in patients with AD, whereas IGF and VEGF did not show significant differences between the AD group and control group. In addition, 23 post-mortem studies were included in the systematic review. Although data from post-mortem brains were not always consistent across studies, most studies suggested decreased BDNF and increased (pro)NGF levels in hippocampus and neocortex of patients with AD. These results provide strong clinical evidence that AD is accompanied by an aberrant neurotrophin profile, and future investigations into neurotrophins as biomarkers (especially CSF BDNF and NGF) and therapeutic targets for AD may be warranted.

Indexed as

Alzheimer DiseaseAutopsyBiomarkersBrainBrain-Derived Neurotrophic FactorHumansBiomarkersBrain-Derived Neurotrophic FactorAlzheimer’s diseaseMeta-analysisNeurotrophic factorNeurotrophinSystematic review

Identifiers

PMID29956088
OpenAlexW2810724956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.