Observational studyIndian journal of pediatrics2018
Prevalence and Predictors of Invasive Fungal Infections in Children with Persistent Febrile Neutropenia Treated for Acute Leukemia - A Prospective Study.
Observational study in Indian journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Antifungal Resistance Among Candida Species: Diagnostic and Clinical Challenges in Specialized Cancer Care Hospital of Lahore.Journal of clinical laboratory analysis · 2025Article
- Clinical pharmacist-led antifungal drug utilization reviews in cancer care hospital: a prospective audit and feedback.JAC-antimicrobial resistance · 2024Article
- Diagnostic and Therapeutic Challenge Caused byPathogens (Basel, Switzerland) · 2024Review
- Invasive fungal infections in children with leukemia in a tertiary hospital in Oman: An eight-year review.Current medical mycology · 2023Article
- Changes in the epidemiology of invasive fungal disease in a Pediatric Hematology and Oncology Unit: the relevance of breakthrough infections.BMC infectious diseases · 2023Article
- Value of diffusion-weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia.Immunity, inflammation and disease · 2023Article
- Article
- Invasive Fungal Infections in Children with Leukemia: Clinical Features and PrognosisTurkish journal of haematology : official journal of Turkish Society of Haematology · 2022Article
- Induction therapy for acute lymphoblastic leukemia: incidence and risk factors for bloodstream infections.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Epidemiology and Antifungal Susceptibility Patterns of Invasive Fungal Infections (IFIs) in India: A Prospective Observational Study.Journal of fungi (Basel, Switzerland) · 2021Article
- Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy.Children (Basel, Switzerland) · 2021Review
- Clinical Characteristics and Predictive Factors of Invasive Fungal Disease in Pediatric Oncology Patients with Febrile Neutropenia in a Country with Limited Resources.Pediatric health, medicine and therapeutics · 2021Article
- Pulmonary Infectious Complications in Children with Hematologic Malignancies and Chemotherapy-Induced Neutropenia.Diseases (Basel, Switzerland) · 2020Review
- Invasive fungal infections in a pediatric hematology-oncology department: A 16-year retrospective study.Current medical mycology · 2020Article
- An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies.Infection and drug resistance · 2020Review
- High incidence of invasive fungal infection during acute myeloid leukemia treatment in a resource-limited country: clinical risk factors and treatment outcomes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Invasive Fungal Disease in Children with Acute Leukemia: The Elusive Culprit.Indian journal of pediatrics · 2018Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo ascertain the prevalence of invasive fungal infections (IFI), predictors of IFI, identify etiological species and outcome (mortality/discharge) in persistent febrile neutropenia in children with acute leukemia.
methodsIt was a prospective, observational study conducted from January 2013 through June 2014 in a tertiary care centre in New Delhi. Children between 1 and 12 y of age, on chemotherapy for acute leukemia with persistent febrile neutropenia (> 96 h) were enrolled. These children were not on any antifungal prophylaxis. Diagnosis of IFI was based on European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. Prevalence and outcome was reported in mean ± 95% CI form and etiological species were presented in the form of the frequency distribution.
resultsThree hundred nineteen episodes involving 187 children of febrile neutropenia were screened and 74 were enrolled. Prevalence of IFI was 22.97% (13.99-34.21). Positive cases were further classified into proven 3(17.6%), probable 11(64.8%) and possible 3(17.6%) according to EORTC/MSG criteria. On multivariate analysis, abnormal CXR and clinical sinusitis were important predictors of IFI. Most common fungi isolated was Aspergillus sp. followed by Candida sp. Mortality rate was 9.45% (3.89-18.52).
conclusionsThus, prevalence of IFI is very high in children with persistent febrile neutropenia who are not on antifungal prophylaxis. Abnormal chest x- ray and clinical sinusitis are important predictors of IFI.
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