Evidence map›Paper›PMID 29955904›Full record

ArticlePediatric radiology2018

Lung and airway shape in neuroendocrine cell hyperplasia of infancy.

Emily J Mastej, Emily M DeBoer, Stephen M Humphries, Marlijne C Cook, Kendall S Hunter, Deborah R Liptzin, Jason P Weinman, Robin R Deterding

Abstract read
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Article in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Emily J MastejDepartment of Pediatrics and Breathing Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, 13123 E. 16th Ave. B-395, Aurora, CO, 80045, USA.
Emily M DeBoerDepartment of Pediatrics and Breathing Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, 13123 E. 16th Ave. B-395, Aurora, CO, 80045, USA. Emily.deboer@childrenscolorado.org.
Stephen M HumphriesDepartment of Radiology, National Jewish Health, Denver, CO, USA.
Marlijne C CookDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kendall S HunterDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Deborah R LiptzinDepartment of Pediatrics and Breathing Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, 13123 E. 16th Ave. B-395, Aurora, CO, 80045, USA.
Jason P WeinmanDepartment of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Robin R DeterdingDepartment of Pediatrics and Breathing Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, 13123 E. 16th Ave. B-395, Aurora, CO, 80045, USA.
University of Colorado Anschutz Medical Campus · USChildren's Hospital Colorado · USNational Jewish Health · USUniversity of Colorado Denver · US

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JURRUS, ELIZABETH · 2012 to 2019
$9.7M
NIGMS NIH HHS P41 GM103545
6 · The paper itself

Abstract

backgroundNeuroendocrine cell hyperplasia of infancy (NEHI) is a rare lung disease associated with significant air trapping. Although chest CT is crucial in establishing a diagnosis, CT and biopsy findings do not reveal airway abnormalities to explain the air trapping.

objectiveWe compared lung and airway morphology obtained from chest CT scans in children with NEHI and control children. In the children with NEHI, we explored relationships between lung and airway shape and lung function. MATERIALS AND

methodsWe performed a retrospective review of children with NEHI who underwent clinical chest CT. We identified control children of similar size and age. We created lung masks and airway skeletons using semi-automated software and compared them using statistical shape modeling methods. Then we calculated a logistic regression model using lung and airway shape to differentiate NEHI from controls, and we compared shape model parameters to lung function measurements.

resultsAirway and lung shapes were statistically different between children with NEHI and controls. We noted a broad lung apex in the children with NEHI and a significantly increased apical anterior-posterior lung diameter. A logistic regression model including lung shape was 90% accurate in differentiating children with NEHI from controls. Correlation coefficients were significant between lung function values and lung and airway shape.

conclusionLung and airway shapes were different between children with NEHI and control children in this cohort. Children with NEHI had an increased anteroposterior diameter of their lungs that might be useful in the diagnostic criteria.

Indexed as

FemaleHumansHyperplasiaInfantLung Diseases, InterstitialMaleNeuroendocrine CellsRadiographic Image Interpretation, Computer-AssistedRare DiseasesRetrospective StudiesTomography, X-Ray ComputedChildrenComputed tomographyInterstitial lung diseaseLungsNeuroendocrine cell hyperplasia of infancyShape modeling

Identifiers

PMID29955904
OpenAlexW2811436028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.