ArticleJournal of experimental botany2018
Rice H2A.Z negatively regulates genes responsive to nutrient starvation but promotes expression of key housekeeping genes.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Epigenetic Regulation of Root-Associated Microbiota: Mechanisms and Horticultural Applications.Plants (Basel, Switzerland) · 2026Review
- The chromatin remodeling factor OsINO80 promotes H3K27me3 and H3K9me2 deposition and maintains TE silencing in rice.Nature communications · 2024Article
- Proteomic profiling ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Contribution of the histone variant H2A.Z to expression of responsive genes in plants.Seminars in cell & developmental biology · 2023Review
- Advances in biological functions and mechanisms of histone variants in plants.Frontiers in genetics · 2023Review
- Transcriptome and Metabolome Analyses Reveal Complex Molecular Mechanisms Involved in the Salt Tolerance of Rice Induced by Exogenous Allantoin.Antioxidants (Basel, Switzerland) · 2022Article
- Histone Variants in the Specialization of Plant Chromatin.Annual review of plant biology · 2022Review
- Transcriptome analysis of a near-isogenic line and its recurrent parent reveals the role of Pup1 QTL in phosphorus deficiency tolerance of rice at tillering stage.Plant molecular biology · 2022Article
- Chromatin remodeling factors OsYAF9 and OsSWC4 interact to promote internode elongation in rice.Plant physiology · 2022Article
- Uncovering the Epigenetic Marks Involved in Mediating Salt Stress Tolerance in Plants.Frontiers in genetics · 2022Review
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- Characterization of contrasting rice (Oryza sativa L.) genotypes reveals the Pi-efficient schema for phosphate starvation tolerance.BMC plant biology · 2021Article
- The histone variant Sl_H2A.Z regulates carotenoid biosynthesis and gene expression during tomato fruit ripening.Horticulture research · 2021Article
- OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice.Nature communications · 2020Article
- NAP1-RELATED PROTEIN1 and 2 negatively regulate H2A.Z abundance in chromatin in Arabidopsis.Nature communications · 2020Article
- Understanding epigenomics based on the rice model.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Low-Phosphate Chromatin Dynamics Predict a Cell Wall Remodeling Network in Rice Shoots.Plant physiology · 2020Article
- H2A Variants inPlant communications · 2020Review
- Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The H2A.Z histone variant plays a role in the modulation of environmental responses, but the nature of the associated mechanisms remains enigmatic. We investigated global H2A.Z deposition and transcriptomic changes in rice (Oryza sativa) upon exposure to phosphate (Pi) deficiency and in response to RNAi knockdown of OsARP6, which encodes a key component of the H2A.Z exchange complex. Both Pi deficiency and OsARP6-knockdown resulted in similar, profound effects on global H2A.Z distribution. H2A.Z in the gene body of stress-responsive genes was negatively correlated with gene expression, and this was more apparent in response to Pi deficiency. In contrast, the role of H2A.Z at the transcription start site (TSS) was more context dependent, acting as a repressor of some stress-responsive genes, but an activator of some genes with housekeeping functions. This was especially evident upon OsARP6-knockdown, which resulted in down-regulation of a number of genes linked to chloroplast function that contained decreases in H2A.Z at the TSS. Consistently, OsARP6-RNAi plants exhibited lower chlorophyll content relative to the wild-type. Our results demonstrate that gene body-localized H2A.Z plays a prominent role in repressing stress-responsive genes under non-inductive conditions, whereas H2A.Z at the TSS functions as a positive or negative regulator of transcription.
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