ArticleCurrent developments in nutrition2018
Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs.
Article in Current developments in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.Nutrients · 2020Pooled it
- Depressive Symptoms Associated with Decreased Choline Intake in Lactating Mothers of Preterm Infants.Nutrients · 2026Article
- Graded supplemental choline chloride fed throughout the grow and finish periods elicited minimal influence on growth performance and carcass characteristics of pigs in a commercial setting.Journal of animal science · 2025Article
- Experimentally induced colitis impacts myelin development and home-cage behavior in young pigs regardless of supplementation with oral gamma-cyclodextrin-encapsulated tributyrin.Frontiers in neuroscience · 2025Article
- The Role of Choline in Neurodevelopmental Disorders-A Narrative Review Focusing on ASC, ADHD and Dyslexia.Nutrients · 2023Review
- Developing a Reference Database for Typical Body and Organ Growth of the Artificially Reared Pig as a Biomedical Research Model.Frontiers in pediatrics · 2021Article
- Pig Brains Have Homologous Resting-State Networks with Human Brains.Brain connectivity · 2019Article
- Article
- Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholine is an essential nutrient that is pivotal to proper brain development. Research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques.
objectiveThis study aimed to characterize the effects of perinatal choline deficiency on gray and white matter development with the use of noninvasive neuroimaging techniques in young pigs.
methodsDuring the last 64 d of the 114-d gestation period Yorkshire sows were provided with a choline-sufficient (CS) or choline-deficient (CD) diet, analyzed to contain 1214 mg or 483 mg total choline/kg diet, respectively. Upon farrowing, pigs (
resultsVBM analysis indicated that prenatally CS pigs exhibited increased (
conclusionsObservations from this study suggest that prenatal choline deficiency results in altered cortical gray matter and reduced white matter in the internal capsule and putamen of young pigs. With the use of noninvasive neuroimaging techniques, results from our study indicate that prenatal choline deficiency greatly alters gray and white matter development in pigs, thereby providing a translational assessment that may be used in clinical populations.
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Registered trials
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