Evidence map›Paper›PMID 29955640›Full record

ArticleBone reports2018

Skeletal vascular perfusion is altered in chronic kidney disease.

Mohammad W Aref, Elizabeth A Swallow, Neal X Chen, Sharon M Moe, Matthew R Allen

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Bone reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mohammad W ArefDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Elizabeth A SwallowDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Neal X ChenDepartment of Medicine, - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States.
Sharon M MoeDepartment of Medicine, - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States.
Matthew R AllenDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USUniversity of Indianapolis · US

Funding

Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
Bone vascular alterations in chronic kidney diseaseF30DK115162 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI AREF, MOHAMMAD WALID · 2017 to 2020
$160k
Treating bone deterioration associated with chronic kidney diseaseI01BX003025 · VA · RLR VA MEDICAL CENTER · PI ALLEN, MATTHEW R · 2016 to 2024
–
BLRD VA I01 BX003025NIAMS NIH HHS T32 AR065971NIDDK NIH HHS F30 DK115162
6 · The paper itself

Abstract

Patients with chronic kidney disease (CKD) are at an alarming risk of cardiovascular disease and fracture-associated mortality. CKD has been shown to have negative effects on vascular reactivity and organ perfusion. Although alterations in bone blood flow are linked to dysregulation of bone remodeling and mass in multiple conditions, changes to skeletal perfusion in the setting of CKD have not been explored. The goal of this study was to establish the effect of CKD on skeletal perfusion in a rat model of CKD. In two experiments with endpoints at 30 and 35 weeks of age, respectively, normal (NL) and Cy/+ (CKD) animals (

Indexed as

Bone marrow perfusionCKD-mineral bone diseaseCortical bone perfusionFluorescent microspheres

Identifiers

PMID29955640
PMCPMC6020396
OpenAlexW2800896542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.