ArticleBone reports2018
Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered.
Article in Bone reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Growth Plate Skeletal Stem Cells and Their Actions Within the Stem Cell Niche.International journal of molecular sciences · 2025Review
- Lactoferrin Stimulates Chondrogenesis and Promotes Healing of the Auricular Elastic Cartilage.International journal of molecular sciences · 2025Article
- The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling.Nature communications · 2024Article
- Stimulation of skeletal stem cells in the growth plate promotes linear bone growth.JCI insight · 2024Article
- Hypertrophic chondrocytes at the junction of musculoskeletal structures.Bone reports · 2023Article
- Look who's TORking: mTOR-mediated integration of cell status and external signals during limb development and endochondral bone growth.Frontiers in cell and developmental biology · 2023Review
- Article
- Review
- GCN5 acetylation is required for craniofacial chondrocyte maturation.Developmental biology · 2020Article
- Home for a rest: stem cell niche of the postnatal growth plate.The Journal of endocrinology · 2020Review
- Postnatal skeletal growth is driven by the epiphyseal stem cell niche: potential implications to pediatrics.Pediatric research · 2020Review
- Niches for Skeletal Stem Cells of Mesenchymal Origin.Frontiers in cell and developmental biology · 2020Review
- Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively.BioMed research international · 2020Article
- Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond.International journal of molecular sciences · 2019Review
- Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.Nature · 2019Article
- Understanding the Cellular and Molecular Mechanisms That Control Early Cell Fate Decisions During Appendicular Skeletogenesis.Frontiers in genetics · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications 2016, 7:11151). Both laboratories employed TSC1-floxed mice crossed with collagen type 2-driven Cre (Col2-Cre), but drew substantially different conclusions. It was reported that activation of mechanistic target of rapamycin complex 1 (mTORC1)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.