Evidence map›Paper›PMID 29955244›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2018

Spin-Lattice Relaxation of Hyperpolarized Metronidazole in Signal Amplification by Reversible Exchange in Micro-Tesla Fields.

Roman V Shchepin, Lamya Jaigirdar, Eduard Y Chekmenev

Abstract read
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Exploring Limits of [1-Small science · 2026
    Article
  2. The journal of physical chemistry. B · 2025
    Article
  3. EfficientJournal of magnetic resonance open · 2025
    Article
  4. The journal of physical chemistry letters · 2024
    Article
  5. Development of Dissolution Dynamic Nuclear Polarization of [Angewandte Chemie (International ed. in English) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Order-UnityChemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  11. Article
  12. Synthetic Approaches forChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  13. Angewandte Chemie (International ed. in English) · 2021
    Article
  14. Quantifying the effects of quadrupolar sinks viaChemical communications (Cambridge, England) · 2020
    Article
  15. Remarkable Levels ofThe journal of physical chemistry. B · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Quasi-Resonance Fluorine-19 Signal Amplification by Reversible Exchange.The journal of physical chemistry letters · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roman V ShchepinVanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee 37232-2310 United States.
Lamya JaigirdarVanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee 37232-2310 United States.
Eduard Y ChekmenevVanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee 37232-2310 United States.

Funding

Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB020323 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2015 to 2016
$416k
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB018014 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2014 to 2015
$407k
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in CancerR21CA220137 · NCI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2017 to 2019
$390k
NCI NIH HHS R21 CA220137NIBIB NIH HHS R21 EB018014NIBIB NIH HHS R21 EB020323
6 · The paper itself

Abstract

Simultaneous reversible chemical exchange of parahydrogen and to-be-hyperpolarized substrate on metal centers enables spontaneous transfer of spin order from parahydrogen singlet to nuclear spins of the substrate. When performed at sub-micro-Tesla magnetic field, this technique of NMR Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH). SABRE-SHEATH has been shown to hyperpolarize nitrogen-15 sites of a wide range of biologically interesting molecules to a high polarization level (

Identifiers

PMID29955244
PMCPMC6017983

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.