ReviewMolecular psychiatry2019
Molecular windows into the human brain for psychiatric disorders.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Identification of variants from gene expression data of opioid-addicted patients.Journal of applied genetics · 2026Article
- Heroin addiction modulates transcription factor binding in regulatory regions of the human putamen.Scientific reports · 2026Article
- Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model.Biological psychiatry · 2025Article
- Decreased voluntary alcohol intake and ventral striatal epigenetic and transcriptional remodeling in male Acss2 KO mice.Neuropharmacology · 2025Article
- Advances in Human Brain Organoids: Methodological Innovations and Future Directions for Drug Discovery.Current drug research reviews · 2025Review
- Review
- Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing.Science advances · 2024Article
- Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture.Research square · 2023Article
- Application of Human Brain Organoids-Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental Diseases.International journal of molecular sciences · 2023Review
- Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders.Brain : a journal of neurology · 2023Article
- Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes.Frontiers in genetics · 2023Article
- Differential expression ofDrug and alcohol dependence reports · 2022Article
- DNA methylation signature of psychological resilience in young adults: Constructing a methylation risk score using a machine learning method.Frontiers in genetics · 2022Article
- Multi-Omics for the Understanding of Brain Diseases.Life (Basel, Switzerland) · 2021Article
- Chromatin accessibility in neuropsychiatric disorders.Neurobiology of learning and memory · 2021Review
- Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice.Frontiers in molecular neuroscience · 2021Article
- Evolution of regulatory signatures in primate cortical neurons at cell-type resolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mitochondria under the spotlight: On the implications of mitochondrial dysfunction and its connectivity to neuropsychiatric disorders.Computational and structural biotechnology journal · 2020Review
- Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers.Scientific reports · 2019Article
- Psychiatry and developmental psychopathology: Unifying themes and future directions.Comprehensive psychiatry · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Delineating the pathophysiology of psychiatric disorders has been extremely challenging but technological advances in recent decades have facilitated a deeper interrogation of molecular processes in the human brain. Initial candidate gene expression studies of the postmortem brain have evolved into genome wide profiling of the transcriptome and the epigenome, a critical regulator of gene expression. Here, we review the potential and challenges of direct molecular characterization of the postmortem human brain, and provide a brief overview of recent transcriptional and epigenetic studies with respect to neuropsychiatric disorders. Such information can now be leveraged and integrated with the growing number of genome-wide association databases to provide a functional context of trait-associated genetic variants linked to psychiatric illnesses and related phenotypes. While it is clear that the field is still developing and challenges remain to be surmounted, these recent advances nevertheless hold tremendous promise for delineating the neurobiological underpinnings of mental diseases and accelerating the development of novel medication strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.