ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Inflaming sex differences in mood disorders.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial.Neurology(R) neuroimmunology & neuroinflammation · 2024Trial
- Depression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers.Translational psychiatry · 2021Trial
- Peripheral biochemical parameters for discrimination between bipolar disorder and major depressive disorder in female patients of reproductive age: a CRP-stratified exploratory study.BMC psychiatry · 2026Article
- PARP Inhibition with 3-Aminobenzimide Attenuates Behavioral, Cardiovascular, and Neuroinflammatory Effects of Chronic Stress.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific Serum Biomarker Associations with Antidepressant Treatment Outcomes in Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Beyond AQP-4: convergent glymphatic-meningeal lymphatic dysfunction underlying multifactorial migraine pathogenesis.Frontiers in immunology · 2026Review
- The emerging role of T cells in depression.Frontiers in psychiatry · 2026Review
- Sex-related molecular phenotypes in anxiety-depressive disorders: a machine learning analysis of routine blood biomarkers.Frontiers in psychiatry · 2026Article
- Gender differences in symptom profiles of individuals being treated for mood disorders.Journal of mood and anxiety disorders · 2025Article
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Psychiatric Comorbidities in Women With Complete Androgen Insensitivity Syndrome or Müllerian Duct Aplasia/Agenesis.The Journal of clinical endocrinology and metabolism · 2025Article
- Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence.Psychiatry research communications · 2025Article
- Sex-specific regulation of microglial MyD88 in HMGB1-Induced anxiety phenotype in mice.Neurobiology of stress · 2025Article
- Gender Differences in Alexithymia, Emotion Regulation, and Impulsivity in Young Individuals with Mood Disorders.Journal of clinical medicine · 2025Article
- The role of cytokines in predicting the therapeutic effect of non-suicidal self-injury in adolescents: a longitudinal study.BMC psychiatry · 2025Article
- Global burden of young-onset dementia, from 1990 to 2021: an age-period-cohort analysis from the global burden of disease study 2021.Translational psychiatry · 2025Article
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Fasudil attenuates lipopolysaccharide-induced cognitive impairment in C57BL/6 mice through anti-oxidative and anti-inflammatory effects: Possible role of aquaporin-4.IBRO neuroscience reports · 2024Article
- Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Microglial MyD88-dependent pathways are regulated in a sex-specific manner in the context of HMGB1-induced anxiety.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Men and women often experience different symptoms or rates of occurrence for a variety of mood disorders. Many of the symptoms of mood disorders overlap with autoimmune disorders, which also have a higher prevalence in women. There is a growing interest in exploring the immune system to provide biomarkers for diagnosis of mood disorders, along with new targets for developing treatments. This review examines known sex differences in the immune system and their relationship to mood disorders. We focus on immune alterations associated with unipolar depression, bipolar depression, and anxiety disorders. We describe work from both basic and clinical research examining potential immune mechanisms thought to contribute to stress susceptibility and associated mood disorders. We propose that sex and age are important, intertwined factors that need to be included in future experimental designs if we are going to harness the power of the immune system to develop a new wave of treatments for mood disorders.
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Registered trials
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