ArticleNature communications2018
Prolonged abstinence from cocaine or morphine disrupts separable valuations during decision conflict.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
- Article
- Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind.Nature neuroscience · 2025Article
- Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner.Science advances · 2025Article
- Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes.Communications biology · 2025Article
- A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.Biological psychiatry · 2024Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behaviour.Addiction biology · 2024Article
- Article
- Measuring excitation-inhibition balance through spectral components of local field potentials.bioRxiv : the preprint server for biology · 2024Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior.bioRxiv : the preprint server for biology · 2023Article
- Differential processing of decision information in subregions of rodent medial prefrontal cortex.eLife · 2023Article
- Sunk cost sensitivity during change-of-mind decisions is informed by both the spent and remaining costs.Communications biology · 2022Article
- Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice.Science advances · 2022Article
- Apparent sunk cost effect in rational agents.Science advances · 2022Article
- A mathematical model of reward-mediated learning in drug addiction.Chaos (Woodbury, N.Y.) · 2022Article
- Parametric shift from rational to irrational decisions in mice.Scientific reports · 2021Article
- Vicarious Trial-and-Error Is Enhanced During Deliberation in Human Virtual Navigation in a Translational Foraging Task.Frontiers in behavioral neuroscience · 2021Article
- Sensitivity to Sunk Costs Depends on Attention to the Delay.Frontiers in psychology · 2021Article
- Neural signatures underlying deliberation in human foraging decisions.Cognitive, affective & behavioral neuroscience · 2019Article
- Learning From Loss After Risk: Dissociating Reward Pursuit and Reward Valuation in a Naturalistic Foraging Task.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Neuroeconomic theories propose changes in decision making drive relapse in recovering drug addicts, resulting in continued drug use despite stated wishes not to. Such conflict is thought to arise from multiple valuation systems dependent on separable neural components, yet many neurobiology of addiction studies employ only simple tests of value. Here, we tested in mice how prolonged abstinence from different drugs affects behavior in a neuroeconomic foraging task that reveals multiple tests of value. Abstinence from repeated cocaine and morphine disrupts separable decision-making processes. Cocaine alters deliberation-like behavior prior to choosing a preferred though economically unfavorable offer, while morphine disrupts re-evaluations after rapid initial decisions. These findings suggest that different drugs have long-lasting effects precipitating distinct decision-making vulnerabilities. Our approach can guide future refinement of decision-making behavioral paradigms and highlights how grossly similar behavioral maladaptations may mask multiple underlying, parallel, and dissociable processes that treatments for addiction could potentially target.
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