Evidence map›Paper›PMID 29954976›Full record

ArticleScience (New York, N.Y.)2018

A method for single-neuron chronic recording from the retina in awake mice.

Guosong Hong, Tian-Ming Fu, Mu Qiao, Robert D Viveros, Xiao Yang, Tao Zhou, Jung Min Lee, Hong-Gyu Park, Joshua R Sanes, Charles M Lieber

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Review
  2. Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Retina-Inspired Bi-Based Terahertz Photonic Neuromorphic Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guosong HongDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8858-4471
Tian-Ming FuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Mu QiaoCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7309-4237
Robert D ViverosJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Xiao YangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-1504-4949
Tao ZhouDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-6507-8912
Jung Min LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-9608-0671
Hong-Gyu ParkDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-6375-0314
Joshua R SanesCenter for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8926-8836
Charles M LieberDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cml@cmliris.harvard.edu.ORCID 0000-0002-6660-2456

Funding

Synaptic Choices in the Retinotectal SystemR37NS029169 · NINDS · HARVARD UNIVERSITY · PI SANES, JOSHUA R · 2013 to 2019
$4.0M
Syringe-Injectable Mesh Electronics for Seamless Integration with the Central Nervous SystemDP1EB025835 · NIBIB · HARVARD UNIVERSITY · PI LIEBER, CHARLES M · 2017 to 2019
$3.5M
Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable ElectronicsR00AG056636 · NIA · STANFORD UNIVERSITY · PI HONG, GUOSONG · 2018 to 2020
$745k
Brain Aging Studies with Single-Neuron Resolution Using Syringe-Injectable ElectronicsK99AG056636 · NIA · HARVARD UNIVERSITY · PI HONG, GUOSONG · 2017 to 2018
$255k
Howard Hughes Medical InstituteNIA NIH HHS K99 AG056636NIA NIH HHS R00 AG056636NIBIB NIH HHS DP1 EB025835NINDS NIH HHS R37 NS029169
6 · The paper itself

Abstract

The retina, which processes visual information and sends it to the brain, is an excellent model for studying neural circuitry. It has been probed extensively ex vivo but has been refractory to chronic in vivo electrophysiology. We report a nonsurgical method to achieve chronically stable in vivo recordings from single retinal ganglion cells (RGCs) in awake mice. We developed a noncoaxial intravitreal injection scheme in which injected mesh electronics unrolls inside the eye and conformally coats the highly curved retina without compromising normal eye functions. The method allows 16-channel recordings from multiple types of RGCs with stable responses to visual stimuli for at least 2 weeks, and reveals circadian rhythms in RGC responses over multiple day/night cycles.

Indexed as

Electrodes, ImplantedAnimalsCircadian RhythmMiceMicroelectrodesNeural PathwaysPhotic StimulationRetinal Ganglion CellsSingle-Cell AnalysisWakefulness

Identifiers

PMID29954976
PMCPMC6047945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.