ArticleThe European respiratory journal2018
Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension.
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Article in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 81 citations in OpenAlex.
- Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial.American journal of respiratory and critical care medicine · 2024Trial
- When Good Biology Meets Negative Clinical Trials: Lessons from PHANTOM and EDIPHY.Annals of the American Thoracic Society · 2026Article
- Observed Weight Gain in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept.Pulmonary circulation · 2026Article
- Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension.bioRxiv : the preprint server for biology · 2026Article
- Metabolomics of Right Ventricular Function in Pulmonary Hypertension.Circulation research · 2026Article
- Cardiomyocyte NLRP3 signaling in right heart failure is sexually dimorphic via estrogen receptor α.bioRxiv : the preprint server for biology · 2026Article
- The Sex Hormone Precursors Dehydroepiandrosterone (DHEA) and Its Sulfate Ester Form (DHEAS): Molecular Mechanisms and Actions on Human Body.International journal of molecular sciences · 2025Review
- Sex differences in pulmonary (arterial) hypertension: does it matter?Current opinion in pulmonary medicine · 2025Review
- Sex-dependent Pathophysiology and Therapeutic Considerations in Right Heart Disease.The Canadian journal of cardiology · 2025Review
- Transcriptional Signatures of the Right Ventricle in End-Stage Heart Failure.Pulmonary circulation · 2025Article
- Mechanisms and treatment of pulmonary arterial hypertension.Nature reviews. Cardiology · 2025Review
- Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes.Cellular & molecular biology letters · 2024Review
- High Pretreatment DHEA Is Associated with Inferior Immunotherapy Response in Metastatic Non-Small Cell Lung Cancer.Cancers · 2024Article
- Non-Interferon-Dependent Role of STING Signaling in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Sex-biased TGFβ signalling in pulmonary arterial hypertension.Cardiovascular research · 2023Review
- Differential drug response in pulmonary arterial hypertension: The potential for precision medicine.Pulmonary circulation · 2023Review
- Review
- Pathophysiology and new advances in pulmonary hypertension.BMJ medicine · 2023Review
- Baseline Sex Differences in Pulmonary Arterial Hypertension Randomized Clinical Trials.Annals of the American Thoracic Society · 2023Article
- Chitinase 3 like 1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension.JCI insight · 2022Article
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Authors and funding
21 authors at 7 institutions in 1 country.
Grayson L BairdDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Christine Archer-ChickoDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R Graham BarrDept of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
David A BluemkeDept of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Andrew E FoderaroDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Jason S FritzDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nicholas S HillDept of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Steven M KawutDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James R KlingerDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Joao A C LimaDept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Christopher J MullinDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Pamela OuyangDept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4925-9059
Harold I PalevskyDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amy J PalmisicanoDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Diane PinderDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ioana R PrestonDept of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Kari E RobertsDept of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
K Akaya SmithDept of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thomas WalshDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.ORCID 0000-0003-2620-6843
Mary WhittenhallDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Corey E VentetuoloDept of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Brown University · USUniversity of Pennsylvania · USTufts University · USJohns Hopkins University · USCenter for Clinical Research (United States) · USColumbia University · USUniversity of Wisconsin–Madison · US
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MUncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI ABBASI, ADEEL, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MEndothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisR01HL086719 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2007 to 2010
$2.0MCigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0MMentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6MAdjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3MSUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642kNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K24 HL103844NHLBI NIH HHS L30 HL115758NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL086719NIGMS NIH HHS P20 GM103652NIH HHS HHSN263201500003I
Abstract
High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged ≥55 years with PAH were matched by age and body mass index to women without cardiovascular disease. Plasma sex hormone levels were measured by immunoassay.Lower levels of DHEA-S (p<0.001) and higher levels of E2 (p=0.02) were associated with PAH. In PAH cases (n=112), lower DHEA-S levels were associated with worse haemodynamics (all p<0.01) and more right ventricular dilatation and dysfunction (both p=0.001). Lower DHEA-S levels were associated with shorter 6-min walking distance (6MWD) (p=0.01) and worse functional class (p=0.004). Each Ln(1 µg·dL
Indexed as
AgedBody Mass IndexCase-Control StudiesConnective Tissue DiseasesDehydroepiandrosterone SulfateEstradiolFemaleHeart Defects, CongenitalHumansHypertension, PulmonaryMaleMiddle AgedPostmenopauseProportional Hazards ModelsRisk FactorsWalk TestDehydroepiandrosterone SulfateEstradiol
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