Evidence map›Paper›PMID 29954852›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Maintenance of Mouse Gustatory Terminal Field Organization Is Dependent on BDNF at Adulthood.

Chengsan Sun, Robin Krimm, David L Hill

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish.International journal of molecular sciences · 2022
    Review
  5. Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chengsan SunDepartment of Psychology, University of Virginia, Charlottesville, Virginia 22904-4400 and.
Robin KrimmDepartment of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292.ORCID 0000-0001-5025-3346
David L HillDepartment of Psychology, University of Virginia, Charlottesville, Virginia 22904-4400 and dh2t@virginia.edu.ORCID 0000-0002-1735-5399
University of Virginia · USUniversity of Louisville · US

Funding

Regulation of taste neuron morphology and functionR01DC007176 · NIDCD · UNIVERSITY OF LOUISVILLE · PI Robin Frances Krimm · 2005 to 2026
$8.1M
ONTOGENY OF CENTRAL NEURAL TASTE RESPONSESR01DC000407 · NIDCD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ERISIR, ALEV · 1989 to 2022
$7.8M
Neural Plasticity in the Adult Gustatory SystemR01DC006938 · NIDCD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HILL, DAVID L · 2004 to 2014
$4.1M
NIDCD NIH HHS R01 DC000407NIDCD NIH HHS R01 DC006938NIDCD NIH HHS R01 DC007176
6 · The paper itself

Abstract

The rodent peripheral gustatory system is especially plastic during early postnatal development and maintains significant anatomical plasticity into adulthood. Thus, taste information carried from the tongue to the brain is built and maintained on a background of anatomical circuits that have the capacity to change throughout the animal's lifespan. Recently, the neurotrophin brain-derived neurotrophic factor (BDNF) was shown to be required in the tongue to maintain normal levels of innervation in taste buds at adulthood, indicating that BDNF is a key molecule in the maintenance of nerve/target matching in taste buds. Here, we tested whether maintenance of the central process of these gustatory nerves at adulthood also relies on BDNF by using male and female transgenic mice with inducible CreERT2 under the control of the keratin 14 promoter or under control of the ubiquitin promoter to remove

Indexed as

AnimalsAxonsBrain-Derived Neurotrophic FactorCell CountFemaleGeniculate GanglionKeratin-14MaleMiceMice, KnockoutMice, TransgenicOrgan SpecificityPromoter Regions, GeneticRecombinant ProteinsSolitary NucleusTasteBdnf protein, mouseBrain-Derived Neurotrophic FactorKeratin-14Recombinant ProteinsUbiquitincytokeratin 14neurotrophinplasticitytasteterminal fieldubiquitin

Identifiers

PMID29954852
PMCPMC6070665
OpenAlexW2810179221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.