Evidence map›Paper›PMID 29954836›Full record

ArticleEMBO reports2018

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site.

Deena M Leslie Pedrioli, Mario Leutert, Vera Bilan, Kathrin Nowak, Kapila Gunasekera, Elena Ferrari, Ralph Imhof, Lars Malmström, Michael O Hottiger

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Deena M Leslie PedrioliDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2342-8010
Mario LeutertDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Vera BilanDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Kathrin NowakDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Kapila GunasekeraDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Elena FerrariDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Ralph ImhofDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Lars MalmströmS3IT and Institute for Computational Science, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9885-9312
Michael O HottigerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland michael.hottiger@dmmd.uzh.ch.ORCID 0000-0002-7323-2270
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite recent mass spectrometry (MS)-based breakthroughs, comprehensive ADP-ribose (ADPr)-acceptor amino acid identification and ADPr-site localization remain challenging. Here, we report the establishment of an unbiased, multistep ADP-ribosylome data analysis workflow that led to the identification of tyrosine as a novel ARTD1/PARP1-dependent

Indexed as

ADP-RibosylationAdenosine Diphosphate RiboseAmino Acid SequenceCarrier ProteinsDNA DamageHeLa CellsHumansMass SpectrometryNuclear ProteinsPeptidesPhosphoproteinsPoly (ADP-Ribose) Polymerase-1ProteomeReproducibility of ResultsRNA, Small InterferingTyrosineAdenosine Diphosphate RiboseCarrier ProteinsHPF1 protein, humanNuclear ProteinsPARP1 protein, humanPeptidesPhosphoproteinsPoly (ADP-Ribose) Polymerase-1ProteomeRNA, Small InterferingTyrosineADP‐ribosylationARTD1/PARP1genotoxic stressHPF1tyrosine ADP‐ribosylation

Identifiers

PMID29954836
PMCPMC6073207
OpenAlexW2810068379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.