SynthesisPediatrics2018
Uropathogen Resistance and Antibiotic Prophylaxis: A Meta-analysis.
Synthesis in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection.Frontiers in medicine · 2022Pooled it
- Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2021Pooled it
- Urinary Secretory-IgA and IgG Responses and Inflammatory Markers in Patients With Pseudomonas aeruginosa Urinary Tract Infections.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Antimicrobial Resistance in Pediatric UTIs with Congenital Urogenital Anomalies: An 11-Year Saudi Retrospective Study.Antibiotics (Basel, Switzerland) · 2026Article
- Clinical Features, Microbial Epidemiology, and Recurrence Risk of Cellulitis in Breast Cancer-Related Lymphedema.Annals of surgical oncology · 2026Article
- Sociodemographic and Clinical Correlates of Multidrug-Resistant Uropathogens in Hospitalized Children.Infection and drug resistance · 2026Article
- Current Evidence on Safety, Efficacy and Efficiency of Sublingual Vaccine UromunePathogens (Basel, Switzerland) · 2025Review
- Children with recurrent urinary tract infections: who are they and why do we need better prevention options?BMC pediatrics · 2025Article
- Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Article
- What paediatricians need to know about modern urologic management of vesicoureteral reflux.Frontiers in pediatrics · 2025Review
- Impact of antibiotic prophylaxis on urinary tract infection recurrence in children Rapid review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Review
- Nur77 protects the bladder urothelium from intracellular bacterial infection.Nature communications · 2024Article
- Abundant urinary amino acids activate glutamine synthetase-encodingJournal of bacteriology · 2024Article
- The distinct transcriptome of virulence-associated phylogenetic group B2Microbiology spectrum · 2023Article
- Multidrug Resistance ofOpen forum infectious diseases · 2023Article
- Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group.Antibiotics (Basel, Switzerland) · 2023Review
- Epidemiology of Antibiotic Resistant Pathogens in Pediatric Urinary Tract Infections as a Tool to Develop a Prediction Model for Early Detection of Drug-Specific Resistance.Antibiotics (Basel, Switzerland) · 2022Article
- Clinical guidelines of UTIs in children: quality appraisal with AGREE II and recommendations analysis.BMJ open · 2022Article
- 2021 Update on Pediatric Overuse.Pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 6 countries.
Funding
Abstract
contextLimited data exist regarding uropathogen resistance in randomized controlled trials of urinary tract infection (UTI) prevention and antibiotic prophylaxis.
objectiveTo assess the effect of prophylaxis on developing a multidrug-resistant first recurrent UTI among children with vesicoureteral reflux. DATA SOURCES: Cochrane Kidney and Transplant Specialized Register through May 25, 2017. STUDY SELECTION: Randomized controlled trials of patients ≤18 years of age with a history of vesicoureteral reflux being treated with continuous antibiotic prophylaxis compared with no treatment or placebo with available antibiotic sensitivity profiles. DATA EXTRACTION: Two independent observers abstracted data and assessed quality and validity per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Adjusted meta-analyses were performed by using a mixed-effects logistic regression model.
resultsOne thousand two hundred and ninety-nine patients contributed 224 UTIs. Patients treated with prophylaxis were more likely to have a multidrug-resistant infection (33% vs 6%, LIMITATIONS: Variables that may contribute to resistance such as medication adherence and antibiotic exposure for other illnesses could not be evaluated.
conclusionsProphylaxis increases the risk of multidrug resistance among recurrent infections. This has important implications in the risk-benefit assessment of prophylaxis as a management strategy and in the selection of empirical treatment of breakthrough infections in prophylaxis patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.